Evaluation of Serum Neutrophil Gelatinase-Associated Lipocalin, Cystatin C, and Clusterin Concentrations in Neonatal Calf Diarrhea
Yazarlar (2)
Doç. Dr. Kenan Çağrı TÜMER Kastamonu Üniversitesi, Türkiye
Doç. Dr. Pelin Fatoş Polat Dinçer Dokuz Eylül Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Large Animal Review (Q4) | ||
| Dergi ISSN | 1124-4593 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2024 |
| Cilt / Sayı / Sayfa | 30 / 1 / 7–11 | DOI | – |
| Makale Linki | https://www.largeanimalreview.com/index.php/lar/article/view/743 | ||
| Özet |
| Neonatal diarrhea adversely affects calf growth, overall health, and productivity. Many factors such as poor environmental conditions, less colostrum intake, infectious and parasitic factors contribute to the development of calf diarrhea. Diarrhea, which is one of the most important causes of calf deaths all over the world, causes significant economic losses if it is not correctly diagnosed and appropriate treatment is not initiated. Systemic inflammatory response and kidney dysfunction are crucial components associated with the pathogenesis and progression of neonatal diarrhea. Early detection and management of these conditions are essential for minimizing their detrimental effects and improving calf health outcomes. However, traditional biomarkers such as haptoglobin and creatinine have limitations in terms of sensitivity, specificity, and accuracy. This study aimed to investigate the potential of emerging markers, including neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, and clusterin, in assessing inflammation and kidney injury in neonatal calves with diarrhea. The levels of NGAL, cystatin C, clusterin, haptoglobin, and creatinine were measured and compared among the groups. The results showed no significant differences in NGAL and cystatin C concentrations between the diarrheic calves and healthy calves. However, there was a significant increase in serum clusterin concentration in calves infected with Escherichia coli (E. coli) compared to other pathogen-infected calves and healthy calves. Moreover, a moderate positive correlation was observed between clusterin and creatinine concentrations, suggesting a potential … |
| Anahtar Kelimeler |
| Calf | clusterin | cystatin C | neonatal diarrhea | neutrophil gelatinase-associated lipocalin |
