Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations
Yazarlar (8)
Prof. Dr. Feray Altan Dokuz Eylül Üniversitesi, Türkiye
Prof. Dr. Orhan Çorum Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Duygu Durna Çorum Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Muammer Elmas Selçuk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Veterinary Medicine and Science (Q2) | ||
| Dergi ISSN | 2053-1095 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 03-2024 |
| Cilt / Sayı / Sayfa | 10 / 3 / – | DOI | 10.1002/vms3.1419 |
| Makale Linki | http://dx.doi.org/10.1002/vms3.1419 | ||
| UAK Araştırma Alanları |
Su Ürünleri Hastalıkları
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| Özet |
| Objective Doxycycline (DO) has been used in fish for a long time, but there are some factors that have not yet been clarified regarding its pharmacokinetic (PK) and pharmacodynamic (PD) properties. Therefore, the aim of this study was to investigate the PK and PK/PD targets of DO after 20 mg/kg intravascular (IV), intramuscular (IM) and oral (OR) gavage administration in rainbow trout (Oncorhynchus mykiss). Methods Plasma samples were collected at specific time points and subsequently analysed by HPLC‐ultraviolet. The PK/PD indices were calculated based on the MIC90 (Aeromonas hydrophila and Aeromonas sobria) values obtained for the respective bacteria and the PK parameters obtained for DO following both IM and OR administration. Results After IV administration, the elimination half‐life (t1/2ʎz), area under the concentration vs. time curve (AUC), apparent volume of distribution at steady‐state … |
| Anahtar Kelimeler |
| Aeromonas hydrophila | Aeromonas sobria | doxycycline | pharmacokinetics | PK–PD integration | rainbow trout |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 4 |
| Google Scholar | 6 |