Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Şengül, Emin; Yıldırım, Serkan; ÇINAR, İrfan; Tekin, Samet; Dağ, Yusuf; Bolat, Merve; Warda, Mohamad

doi:10.1007/s12011-024-04064-0

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Yazarlar (7)

Prof. Dr. Emin Şengül Atatürk Üniversitesi, Türkiye

Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye

Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye

Dr. Öğr. Üyesi Samet Tekin Atatürk Üniversitesi, Türkiye

Arş. Gör. Yusuf Dağ Atatürk Üniversitesi, Türkiye

Dr. Öğr. Üyesi Merve Bolat Atatürk Üniversitesi, Türkiye

Mohamad Warda
Atatürk Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Biological Trace Element Research (Q2)
Dergi ISSN	0163-4984 Dergi Bilgileri (2024)
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	01-2024
Kabul Tarihi	06-01-2024	Yayınlanma Tarihi	19-01-2024
Cilt / Sayı / Sayfa	202 / 11 / 5106–5117	DOI	10.1007/s12011-024-04064-0
Makale Linki	https://link.springer.com/article/10.1007/s12011-024-04064-0
UAK Araştırma Alanları	Tıbbi Farmakoloji

Özet

Cadmium (Cd) is a toxic heavy metal with significant environmental health hazards. It enters the body through various routes with tissue accumulation. The relatively longer half-life with slow body clearance significantly results in hepatotoxicity during its liver detoxification. Therefore, researchers are exploring the potential use of herbal-derived phytocomponents to mitigate their toxicity. Here, we investigated, for the first time, the possible ameliorative effect of the phytochemical Morin (3,5,7,29,49-pentahydroxyflavone) against acute Cd-induced hepatotoxicity while resolving its underlying cellular mechanisms in a rat animal model. The study involved 50 adult male Sprague–Dawley rats weighing 200–250 g. The animals were divided into five equal groups: control, Cd, Morin100 + Cd, Morin200 + Cd, and Morin200. The 2nd, 3rd, and 4th groups were intraperitoneally treated with Cd (6.5 mg/kg), while the 3rd, 4th …

Anahtar Kelimeler

Pdf İndir

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	25
Scopus	22
Google Scholar	28

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Dergi Adı	BIOLOGICAL TRACE ELEMENT RESEARCH
Kısa Adı	BIOL TRACE ELEM RES
Yayıncı	SPRINGERNATURE
Açık Erişim	Evet
ISSN	0163-4984
E-ISSN	1559-0720
Wos Quartile	Q2
Scopus Quartile	Q1
Tarandığı Indeksler	SCIE , Scopus
WoS Kategoriler	BIOCHEMISTRY & MOLECULAR BIOLOGY \| ENDOCRINOLOGY & METABOLISM
Scopus Kategoriler	INORGANIC CHEMISTRY \| BIOCHEMISTRY \| BIOCHEMISTRY (MEDICAL) \| CLINICAL BIOCHEMISTRY \| ENDOCRINOLOGY, DIABETES AND METABOLISM \| MEDICINE (MISCELLANEOUS)

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Paylaş