Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Şengül, Emin; Yıldırım, Serkan; ÇINAR, İrfan; Tekin, Samet; Dağ, Yusuf; Bolat, Merve; Warda, Mohamad

doi:10.1007/s12011-024-04064-0

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Yazarlar (7)

Prof. Dr. Emin Şengül Atatürk Üniversitesi, Türkiye

Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye

Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye

Samet Tekin Atatürk Üniversitesi, Türkiye

Yusuf Dağ Atatürk Üniversitesi, Türkiye

Merve Bolat Atatürk Üniversitesi, Türkiye

Mohamad Warda Atatürk Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Biological Trace Element Research (Q2)
Dergi ISSN	0163-4984 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	01-2024
Cilt / Sayı / Sayfa	202 / 11 / 5106–5117	DOI	10.1007/s12011-024-04064-0
Makale Linki	https://link.springer.com/article/10.1007/s12011-024-04064-0

Özet

Cadmium (Cd) is a toxic heavy metal with significant environmental health hazards. It enters the body through various routes with tissue accumulation. The relatively longer half-life with slow body clearance significantly results in hepatotoxicity during its liver detoxification. Therefore, researchers are exploring the potential use of herbal-derived phytocomponents to mitigate their toxicity. Here, we investigated, for the first time, the possible ameliorative effect of the phytochemical Morin (3,5,7,29,49-pentahydroxyflavone) against acute Cd-induced hepatotoxicity while resolving its underlying cellular mechanisms in a rat animal model. The study involved 50 adult male Sprague–Dawley rats weighing 200–250 g. The animals were divided into five equal groups: control, Cd, Morin100 + Cd, Morin200 + Cd, and Morin200. The 2nd, 3rd, and 4th groups were intraperitoneally treated with Cd (6.5 mg/kg), while the 3rd, 4th …

Anahtar Kelimeler

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	20
Scopus	20
Google Scholar	24

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Dergi Adı	BIOLOGICAL TRACE ELEMENT RESEARCH
Yayıncı	Springer
Açık Erişim	Hayır
ISSN	0163-4984
E-ISSN	1559-0720
CiteScore	9,2
SJR	0,810
SNIP	1,109

Mitigation of Acute Hepatotoxicity Induced by Cadmium Through Morin: Modulation of Oxidative and Pro-apoptotic Endoplasmic Reticulum Stress and Inflammatory Responses in Rats.

Paylaş