| Yazarlar |
Dr. Öğr. Üyesi İdris KOCATÜRK
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Sedat GÜLTEN
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Bünyamin ECE
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Fatma Mutlu KUKUL GÜVEN
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Neurogenic inflammation plays a significant role in the pathogenesis of migraines. This study aimed to investigate the serum levels of prostaglandin E2 (PGE2), lipoxin A4 (LXA4), and other inflammatory biomarkers (C-reactive protein, fibrinogen) in migraine patients. In total, 53 migraine patients and 53 healthy controls were evaluated. Blood serum samples were collected during both attack and interictal periods and compared with the control group. In both the attack and interictal periods, PGE2 and LXA4 values were significantly lower in migraine patients compared to the control group (p < 0.001). Additionally, PGE2 values during the attack period were significantly higher than those during the interictal period (p = 0.016). Patients experiencing migraine attacks lasting ≥ 12 h had significantly lower serum PGE2 and LXA4 levels compared to those with attacks lasting < 12 h (p = 0.028 and p = 0.009, respectively). In ROC analysis, cut-off values of 332.7 pg/mL for PGE2 and 27.2 ng/mL for LXA4 were determined with 70–80% sensitivity and specificity. In conclusion, PGE2 and LXA4 levels are significantly lower in migraine patients during both interictal and attack periods. Additionally, the levels of LXA4 and PGE2 decrease more with the prolongation of migraine attack duration. Our findings provide a basis for future treatment planning. |
| Anahtar Kelimeler |
| C-reactive protein | fibrinogen | inflammation | lipoxin A4 | migraine | prostaglandin E2 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Diagnostics |
| Dergi ISSN | 2075-4418 |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2024 |
| Cilt No | 14 |
| Sayı | 6 |
| Doi Numarası | 10.3390/diagnostics14060635 |
| Atıf Sayıları |
