Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells
Yazarlar (3)
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Doç. Dr. Betül Gıdık Bayburt Üniversitesi, Türkiye
Doç. Dr. Ebubekir Dirican Bilecik Şeyh Edabali University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Biology Reports (Q3) | ||
| Dergi ISSN | 0301-4851 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2024 |
| Cilt / Sayı / Sayfa | 51 / 1 / 491–0 | DOI | 10.1007/s11033-024-09453-1 |
| Makale Linki | https://doi.org/10.1007/s11033-024-09453-1 | ||
| Özet |
| BackgroundThis study aimed to investigate the cytotoxic, apoptotic, invasion, metastasis, and heat shock proteins (HSPs) effects of N. sativa oil on breast and gastric cancer cells.MethodsWe assessed the cytotoxic and apoptotic effects of various concentrations of N. sativa oil (10-50-100-200 µg/mL) on MCF7 breast cancer and AGS, an adenocarcinoma of the gastric cell line, at 24, 48 and 72 h using the MTT test. Additionally, the expression of the Caspase-3, BCL2/Bax, MMP2-9 and HSP60-70 gene was examined using RT-PCR in cell lines treating with N. sativa.ResultsThe MTT experiments demonstrate that N. sativa has a time and dose-dependent inhibitory effect on the proliferation of MCF7 and AGS cancer cells. The vitality rates of MCF7 and AGS cells treated with N. sativa were 77.04–67.50% at 24 h, 65.28–39.14% at 48 h, and 48.95–32.31% at 72 h. The doses of 100 and 200 µg/mL were shown to be the … |
| Anahtar Kelimeler |
| AGS | HSPs | MCF7 | MMPs | N. sativa | RT PCR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 7 |
| Google Scholar | 9 |