Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

Altan, Feray; Çorum, Orhan; Çorum, Duygu Durna; Üney, Kamil; TERZİ, Ertuğrul; BİLEN, Soner; SÖNMEZ, Adem Yavuz; Elmas, Muammer

doi:10.1002/vms3.1419

Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

Yazarlar (8)

Prof. Dr. Feray Altan Dokuz Eylül Üniversitesi, Türkiye

Prof. Dr. Orhan Çorum Mustafa Kemal Üniversitesi, Türkiye

Doç. Dr. Duygu Durna Çorum Mustafa Kemal Üniversitesi, Türkiye

Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye

Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye

Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye

Doç. Dr. Adem Yavuz SÖNMEZ Kastamonu Üniversitesi, Türkiye

Prof. Dr. Muammer Elmas Selçuk Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Veterinary Medicine and Science (Q2)
Dergi ISSN	2053-1095 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	03-2024
Cilt / Sayı / Sayfa	10 / 3 / –	DOI	10.1002/vms3.1419
Makale Linki	https://doi.org/10.1002/vms3.1419
UAK Araştırma Alanları	Su Ürünleri Yetiştiriciliği

Özet

Objective: Doxycycline (DO) has been used in fish for a long time, but there are some factors that have not yet been clarified regarding its pharmacokinetic (PK) and pharmacodynamic (PD) properties. Therefore, the aim of this study was to investigate the PK and PK/PD targets of DO after 20 mg/kg intravascular (IV), intramuscular (IM) and oral (OR) gavage administration in rainbow trout (Oncorhynchus mykiss). Methods: Plasma samples were collected at specific time points and subsequently analysed by HPLC-ultraviolet. The PK/PD indices were calculated based on the MIC90 (Aeromonas hydrophila and Aeromonas sobria) values obtained for the respective bacteria and the PK parameters obtained for DO following both IM and OR administration. Results: After IV administration, the elimination half-life (t1/2ʎz), area under the concentration vs. time curve (AUC), apparent volume of distribution at steady-state and total body clearance of DO were 34.81 h, 723.82 h µg/mL, 1.24 L/kg and 0.03 L/kg/h, respectively. The t1/2λz of the DO was found to be 37.39 and 39.78 h after IM, and OR administration, respectively. The bioavailability was calculated 57.02% and 32.29%, respectively, after IM and OR administration. The MIC90 of DO against A. hydrophila and A. sobria was 4 µg/mL. The PK/PD integration showed that DO (20 mg/kg dose) for A. hydrophila and A. sobria with MIC90 ≤4 µg/mL achieved target AUC/MIC value after IM administration. Conclusions: These results suggest that when rainbow trout was treated with 20 mg/kg IV and IM administered DO, therapeutically effective concentrations were reached in the control of infections caused by A. hydrophila and A. sobria.

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Atıf Sayıları
Scopus	4

Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

Dergi Adı	Veterinary Medicine and Science
Yayıncı	Wiley-Blackwell Publishing Ltd
Açık Erişim	Evet
E-ISSN	2053-1095
CiteScore	3,5
SJR	0,551
SNIP	0,909

Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations

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