The Investigation of Sequence-dependent Interaction of Messenger RNA Binding to Carbon Nanotube
Yazarlar (3)
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Science And Research Branch, İran
N. Karachi
Islamic Azad University, Science And Research Branch, İran
Islamic Azad University, Science And Research Branch, İran
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN Islamic Azad University, Qom Branch, İran
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Fullerenes Nanotubes and Carbon Nanostructures (Q3) | ||
| Dergi ISSN | 1536-383X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2014 |
| Cilt / Sayı / Sayfa | 22 / 7 / 643–662 | DOI | 10.1080/1536383X.2012.717557 |
| Makale Linki | http://dx.doi.org/10.1080/1536383x.2012.717557 | ||
| UAK Araştırma Alanları |
Fiziksel Kimya
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| Özet |
| To investigate carbon nanotubes (CNTs) as gene delivery vehicles, it is essential to characterize their interactions with mRNA. Messenger RNA is a powerful tool for controlling the expression of genes in biomedical applications. In the present report, we study the interactions of single-walled CNT with three codons of mRNA(UGC,GAC,CAG) by using MM, AM1,HF and DFT (B3LYP) methods with STO-3G and 3-21G basis sets in gas phase. To estimate the stability of Nanotubes- mRNA complexes total energy of the systems were determined. The varieties of obtained energy data suggest the relation between the stability of complexes as this order: CAG > GAC > UGC. According to the ability of NMR in providing detailed information about the structure and chemical environment of molecules, this technique has been carried out by supposing gauge-included atomic orbital (GIAO). Considering on the calculated results … |
| Anahtar Kelimeler |
| carbon nanotubes (CNTs) | density functional theory (DFT) | Hartree-Fock (HF) | Messenger RNA (mRNA) |
| Atıf Sayıları | |
| Web of Science | 21 |
| Scopus | 88 |
| Google Scholar | 54 |