| Yazarlar |
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Ab initio (RHF/STO-3G) quantum chemical calculations using the self-consistent reaction field (SCRF) model were carried out to analyze the effect of solvent polarity on the relative Gibbs free energies, the dipole moments, and the structural stability of peptide macrocycles based on unsubstituted cyclo[Gly6] and its trisubstituted derivatives containing Me, NH2, or OH groups at the Cα atom. The macrocycles studied are stable in water at both room temperature and at body fever temperature, which is important for the design of a stable nanovehicle for drug delivery in water. © 2011 Springer-Verlag. |
| Anahtar Kelimeler |
| drug delivery | peptide macrocycles | restricted Hartree-Fock approximation (RHF) | self-consistent reaction field (SCRF) model |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayımlanan tam makale |
| Dergi Adı | Russian Chemical Bulletin |
| Dergi ISSN | 1066-5285 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2011 |
| Cilt No | 60 |
| Sayı | 2 |
| Sayfalar | 238 / 241 |
| Doi Numarası | 10.1007/s11172-011-0039-5 |
| Makale Linki | http://dx.doi.org/10.1007/s11172-011-0039-5 |
| Atıf Sayıları | |
| WoS | 34 |
| SCOPUS | 46 |
| Google Scholar | 41 |
