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Akademisyenler > Fatemeh MOLLAAMIN > Yayın Detayı

Biophysical chemistry of macrocycles for drug delivery: A theoretical study      
Yazarlar (1)
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN Dr. Öğr. Üyesi Fatemeh MOLLAAMIN
Kastamonu Üniversitesi, Türkiye
Devamını Göster
Özet
Ab initio (RHF/STO-3G) quantum chemical calculations using the self-consistent reaction field (SCRF) model were carried out to analyze the effect of solvent polarity on the relative Gibbs free energies, the dipole moments, and the structural stability of peptide macrocycles based on unsubstituted cyclo[Gly6] and its trisubstituted derivatives containing Me, NH2, or OH groups at the Cα atom. The macrocycles studied are stable in water at both room temperature and at body fever temperature, which is important for the design of a stable nanovehicle for drug delivery in water. © 2011 Springer-Verlag.
Anahtar Kelimeler
drug delivery | peptide macrocycles | restricted Hartree-Fock approximation (RHF) | self-consistent reaction field (SCRF) model
Makale Türü Özgün Makale
Makale Alt Türü SCOPUS dergilerinde yayımlanan tam makale
Dergi Adı Russian Chemical Bulletin
Dergi ISSN 1066-5285 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 02-2011
Cilt No 60
Sayı 2
Sayfalar 238 / 241
Doi Numarası 10.1007/s11172-011-0039-5
Makale Linki http://dx.doi.org/10.1007/s11172-011-0039-5
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 46
SCOPUS 66
Google Scholar 53
Biophysical chemistry of macrocycles for drug delivery: A theoretical study

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