Biophysical chemistry of macrocycles for drug delivery: a theoretical study
Yazarlar (3)
B. Khalili Hadad
Islamic Azad University, İran
Islamic Azad University, İran
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN Islamic Azad University, Qom Branch, İran
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Science And Research Branch, İran
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Russian Chemical Bulletin (Q3) | ||
| Dergi ISSN | 1066-5285 Dergi Bilgileri (2011) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2011 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-02-2011 |
| Cilt / Sayı / Sayfa | 60 / 2 / 238–241 | DOI | 10.1007/s11172-011-0039-5 |
| Makale Linki | http://dx.doi.org/10.1007/s11172-011-0039-5 | ||
| UAK Araştırma Alanları |
Fiziksel Kimya
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| Özet |
| Ab initio (RHF/STO-3G) quantum chemical calculations using the self-consistent reaction field (SCRF) model were carried out to analyze the effect of solvent polarity on the relative Gibbs free energies, the dipole moments, and the structural stability of peptide macrocycles based on unsubstituted cyclo[Gly6] and its trisubstituted derivatives containing Me, NH2, or OH groups at the Cα atom. The macrocycles studied are stable in water at both room temperature and at body fever temperature, which is important for the design of a stable nanovehicle for drug delivery in water. |
| Anahtar Kelimeler |
| drug delivery | peptide macrocycles | restricted Hartree-Fock approximation (RHF) | self-consistent reaction field (SCRF) model |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 63 |
| Scopus | 90 |
| Google Scholar | 86 |