| Yazarlar |
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN
Kastamonu Üniversitesi, Türkiye |
| Özet |
| We know that vinblastine, as one of the vinca alkaloids, has played a major role in cancer chemotherapy by inhibiting the polymerisation of tubulin into microtubules. We present an in-depth investigation of the structural, infrared (IR) spectra of vinblastine. The structure of vinblastine is theoretically investigated using the density functional theory and Hartree-Fock levels of theory with the standard 6-31gz.ast and 6-31gz.ast z.ast basis sets. The vibrational spectral data obtained from IR spectra are assigned modes based on the results of the theoretical calculations as intensity and frequency curves. The fundamental vibrational modes were characterised depending on the stability of vinblastine in different dielectric constants. Thermodynamic analysis of data demonstrates good correlation of vinblastine at various media by SCRF-Onsager model with linear coefficient (R2). Thus, the goal of this article is to evaluate and quantify the molecular basis for vinblastine structure in variant positions. © 2011 Taylor & Francis. |
| Anahtar Kelimeler |
| DFT | Intensity | SCRF | Thermodynamic properties | Vibrational frequency | Vinblastine |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayımlanan tam makale |
| Dergi Adı | Physics and Chemistry of Liquids |
| Dergi ISSN | 0031-9104 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2011 |
| Cilt No | 49 |
| Sayı | 3 |
| Sayfalar | 318 / 336 |
| Doi Numarası | 10.1080/00319100903456121 |
| Makale Linki | http://dx.doi.org/10.1080/00319100903456121 |
| Atıf Sayıları | |
| WoS | 42 |
| SCOPUS | 91 |
| Google Scholar | 74 |
