| Yazarlar |
Turker Oba
|
|
Nilgun Solmaz
|
Dr. Öğr. Üyesi Barış KÖMÜR
Kastamonu Üniversitesi |
|
Feyza Onder
|
| Özet |
| Aim: The vascular theory is thought to have an important place in the pathophysiology of glaucoma. In the present study, we aimed to analyze the structural and vascular changes in both eyes of patients with glaucoma at different stages and to investigate the relationship between structural and vascular structures. Methods: In this prospective cross-sectional study conducted between 2018 and 2019, 54 eyes of 27 patients with bilateral asymmetric glaucoma were included. Eyes with glaucoma were evaluated into 2 groups: an earlier stage and an advanced stage. All data is provided from the optical coherence tomography angiography (OCTA) device. The retinal nerve fiber layer (RNFL), ganglion cell inner plexiform layer (GCIPL) thickness, and rim area (RA) were measured using optical coherence tomography (OCT). The optic nerve head total (tVD), peripapillary (ppVD), intradisc (idVD), macular superficial (msVD), parafoveal (pasVD), perifoveal (pesVD), and deep macular vascular density values were compared with using OCTA. The correlation was investigated between thinning in the structural parameters and a decrease in the vascular density parameters. Results: There was a significant difference in both optic nerve head vascular density parameters (tVD, ppVD) and superficial macular vascular density parameters between the eyes with asymmetric glaucoma (p<0.001). The thinning of macular GCIPL, which was very strongly correlated with the change in optic nerve perfusion (tVD, ppVD) (r=0.899 and 0.892, p<0.001), was well correlated with the change in msVD and pesVD (r=0.642 and 0.574). The correlation of RNFL with tVD and ppVD was high (r=0.741 and 0.813), and the correlation with msVD and pesVD was moderate (r=0.480 and 0.494). Macular pasVD, deep vascular density, and idVD showed no correlation with changes in structural parameters. Conclusion: As the stage progresses, both the optic nerve head and macular perfusion are impaired in glaucoma. Macular superficial vascular density is affected more than deep vascular density. Thinning in the structural parameters correlates mostly with optic nerve head tVD and ppVD parameters. |
| Anahtar Kelimeler |
| Optical coherence tomography angiography | glaucoma | microvascular density | angiography |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI |
| Dergi ISSN | 1302-0072 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2022 |
| Cilt No | 60 |
| Sayı | 2 |
| Sayfalar | 138 / 144 |
| Doi Numarası | 10.4274/haseki.galenos.2022.7540 |
| Atıf Sayıları | |
| WoS | 1 |
