| Yazarlar |
Dr. Öğr. Üyesi Ömer DENİZ
Kastamonu Üniversitesi, Türkiye |
EKİNCİ GENCAY
Erciyes Üniversitesi, Türkiye |
|
ONMAZ ALİ CESUR
Erciyes Üniversitesi, Türkiye |
|
Derelli Fatih Mehmet
|
|
Fazio Francesco
|
|
Aragona Francesca
|
|
Hoven Ren´e van den
|
| Özet |
| Rhodococcus equi (R. equi), a gram-positive facultative intracellular pathogen, is a common cause of pneumonia in foals and represents a major cause of disease and death. The aim of the present study was to investigate the time-depended changes in White Blood Cells (WBC), basophils (Baso), neutrophils (Neu), lymphocytes (Lymf), monocytes (Mon), eosinophils (Eos), platelet (PLT) counts, fibrinogen (Fbg) concentration, interferon (IFN-α, IFN-γ) and interleukins (IL-2 and IL-10) in foals with clinical R. equi pneumonia. The main treatment was with azithromycin-rifampicin for 14 days. Blood was sampled prior to, 7 and 14 days after starting therapy. Treatment was associated with significantly decreased counts of WBC, (25.6 ± 6.7 and 14.2 ± 2,7 × 103/ml), Neu (18.6 ±6.2 and 10.7 ± 3.1 × 103/ml), Mon (1.5 ± 0.5 and 0.9 ± 0.2 × 103/ml) and Fbg (539 ± 124 and 287 ± 26 g/dl) between day 0 and day 14. IL-2 and IL-10 concentrations were significantly increased (P = 0.028, P = 0.013, respectively) after treatment, whereas IFN-α and IFN-γ concentrations were not. The diagnostic potentials of INF-α, INF-γ, IL-2 and IL-10 per se seems not very high, however, the study suggests that the activity change of selected interleukins in the course of the disease may be associated with amelioration. We concluded that patterns of serum concentration changes of INF-α, INF-γ, IL-2 and IL-10 may help in the study of the innate immune response in foals during infection and treatment of R. equi pneumonia. |
| Anahtar Kelimeler |
| Azithromycin-rifampicin | Cytokines | Foal | Innate immunity | Pneumonia | Rhodococcus equi |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Equine Veterinary Science |
| Dergi ISSN | 0737-0806 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2024 |
| Cilt No | 138 |
| Sayı | 1 |
| Doi Numarası | 10.1016/j.jevs.2024.105103 |
| Makale Linki | http://dx.doi.org/10.1016/j.jevs.2024.105103 |
| Atıf Sayıları |
