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Evaluation of possible COVID-19 reinfection in children: A multicenter clinical study: COVID-19 reinfection in children   
Yazarlar
İrem Ceren Erbaş
Dokuz Eylül Üniversitesi, Turkey
Yıldız Ekemen Keleş
Tepecik Training and Research Hospital, Turkey
Emine Hafize Erdeniz
Ondokuz Mayis Üniversitesi, Turkey
Doç. Dr. Ayşe YILMAZ
Kastamonu Üniversitesi, Türkiye
Edanur Yeşil
T. C. Sağlık Bakanlığı, Mersin Devlet Hastanesi, Turkey
Özlem Çakıcı
Kocaeli Üniversitesi, Turkey
Mehtap Akça
Mersin Üniversitesi, Turkey
Nursel Kara Ulu
Gazi University, Faculty of Medicine, Turkey
Fatih Dinç
Dokuz Eylül Üniversitesi, Turkey
Dilek Yılmaz Çiftdoğan
Tepecik Training and Research Hospital, Turkey
Selim Öncel
Kocaeli Üniversitesi, Turkey
Necdet Kuyucu
Mersin Üniversitesi, Turkey
Anıl Tapısız
Gazi University, Faculty of Medicine, Turkey
Nurşen Belet
Dokuz Eylül Üniversitesi, Turkey
Özet
Background: Although it was originally unknown whether there would be cases of reinfection of coronavirus disease 2019 (COVID-19) as seen with other coronaviruses, cases of reinfection were reported from various regions recently. However, there is little information about reinfection in children. Methods: In this study, we aimed to investigate the incidence and clinical findings of reinfection in pediatric patients who had recovered from COVID-19. We retrospectively evaluated all patients under 18 years of age with COVID-19 infection from a total of eight healthcare facilities in Turkey, between March 2020 and July 2021. Possible reinfection was defined as a record of confirmed COVID-19 infection based on positive reverse transcription-polymerase chain reaction (RT-PCR) test results at least 3 months apart. Results: A possible reinfection was detected in 11 out of 8840 children, which yielded an incidence of 0.12%. The median duration between two episodes of COVID-19 was 196 (92–483) days. When initial and second episodes were compared, the rates of symptomatic and asymptomatic disease were similar for both, as was the severity of the disease (p = 1.000). Also, there was no significant difference in duration of symptoms (p = 0.498) or in hospitalization rates (p = 1.000). Only one patient died 15 days after PCR positivity, which resulted in a 9.1% mortality rate for cases of reinfection in pediatric patients. Conclusion: We observed that children with COVID-19 were less likely to be exposed to reinfection when compared with adults. Although the clinical spectrum of reinfection was mostly similar to the first episode, we reported death of a healthy child during the reinfection.
Anahtar Kelimeler
Children | COVID-19 | Pediatrics | Reinfection | SARS-CoV-2
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Archives de Pediatrie
Dergi ISSN 0929-693X
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 04-2023
Cilt No 30
Sayı 3
Sayfalar 187 / 191
Doi Numarası 10.1016/j.arcped.2023.01.008