In Situ Drug Delivery Investigation through Characterization and Application of Carbon-Based Nanomaterials: A Promising Approach for Treating Viral Diseases
Yazarlar (2)
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN Kastamonu Üniversitesi, Türkiye
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Central Tehran Branch, İran
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Biological Regulators and Homeostatic Agents | ||
| Dergi ISSN | 0393-974X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Exp, SCOPUS, Biological Abstracts, Biosis Previews, Biosis Selective Coverage Shared, Curation, Current Contents Life Sciences, Derwent Drug File, Essential Science Indicators, Pdf2xml, Pdf2xml, Reference Master, Sophia | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 38 / 3 / 1961–1973 | DOI | 10.23812/j.biol.regul.homeost.agents.20243803.153 |
| Makale Linki | https://unis.kastamonu.edu.tr/yayin-detay/2_CpGpDZG_91/in-situ-drug-delivery-investigation-through-characterization-and-application-of-carbon-based-nanomaterials-a-promising-approach-for-treating-viral-diseases | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| Background This study focuses on a medication targeting the primary protease of severe acute respiratory syndrome coron-avirus 2 (SARS-CoV-2), aiming to inhibit in vitro viral replication across diverse experiments. At the onset of the coronavirus disease of 2019 (COVID-19) pandemic, only general therapy was available; however, an emergency application license has recently been granted for an oral antiviral in the U.S. Nirmatrelvir, an antiviral drug developed by Pfizer, operates as an orally effective 3 Cysteine-like protease inhibitor. Methods This work evaluates the inhibitory potential of nirmatrelvir against the coronavirus when delivered using carbon nano-materials. The direct electron transfer principle, elucidated through the quantum mechanics method of density functional theory (DFT), guides the drug delivery process. The evaluation involves the Becke, 3-parameter, Lee--Yang--Parr (B3LYP)/6-311+G (d … |
| Anahtar Kelimeler |
| (5,5) armchair CNT | COVID-19 | drug delivery | nirmatrelvir drug |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 2 |
| Google Scholar | 4 |