Enhanced anticancer effect of newly synthesised albumin-bound Fe(III)-S-Methyl-thiosemicarbazones on breast cancer cells
Yazarlar (8)
Ferdane Danışman-Kalındemirtaş
Erzincan Binali Yıldırım Üniversitesi, Türkiye
Erzincan Binali Yıldırım Üniversitesi, Türkiye
Serap Erdem-Kuruca İstanbul Atlas Üniversitesi, Türkiye
Gökçe Erdemir Cilasun İstanbul Tıp Fakültesi, Türkiye
Esra Sert Istanbul Üniversitesi, Türkiye
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Prof. Dr. Tülay Bal Demirci Istanbul University-Cerrahpasa, Türkiye
Bahri Ülküseven Istanbul University-Cerrahpasa, Türkiye
İshak Afşin Kariper Erciyes Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Taibah University for Science (Q1) | ||
| Dergi ISSN | 1658-3655 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2024 |
| Cilt / Sayı / Sayfa | 18 / 1 / 2375454–0 | DOI | 10.1080/16583655.2024.2375454 |
| Makale Linki | http://dx.doi.org/10.1080/16583655.2024.2375454 | ||
| Özet |
| Thiosemicarbazones and their analogues are of significant interest due to their antiviral, antibacterial and anticancer properties. Recent advancements in nanoparticle-based therapeutics have enabled targeted cancer cell treatment while minimizing harm to healthy cells. This study focused on encapsulating patented N(1)-R1-salicylidene-N(4)-R2-salicylidene-S-methylisothiosemicarbazone complexes into albumin nanocarriers, creating albumin-bound Fe(III)-S-methyl-thiosemicarbazone (ALB-FeTc) nanoparticles via a novel UV-C lamp-assisted method. The nanoparticles were characterized using FTIR, UV-Vis, DLS and EDX-SEM. Cytotoxicity was evaluated in MCF-7 breast cancer cells and HUVEC cells using an MTT assay. Fluorescence microscopy and flow cytometry were employed to investigate the mechanism of cell death. The study demonstrated strong cytotoxicity of FeTcs against cancer cells, with … |
| Anahtar Kelimeler |
| breast cancer | Iron Thiosemicarbazone | MCF-7 | Nano albumin | Research&Development (R&D) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 4 |
| Google Scholar | 4 |