| Yazarlar |
Ferdane Danışman Kalındemirtaş
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Dürdane Serap Kuruca
İstanbul Atlas Üniversitesi, Türkiye |
|
Gökçe Erdemir Cilasun
Biruni Üniversitesi, Türkiye |
|
Esra Sert
|
Doç. Dr. Dilşad ÖZERKAN
Kastamonu Üniversitesi, Türkiye |
|
Tülay Bal Demirci
Türkiye |
|
Bahri Ülküseven
Türkiye |
| Özet |
| Thiosemicarbazones and their analogues are of significant interest due to their antiviral, antibacterial and anticancer properties. Recent advancements in nanoparticle-based therapeutics have enabled targeted cancer cell treatment while minimizing harm to healthy cells. This study focused on encapsulating patented N(1)-R1-salicylidene-N(4)-R2-salicylidene-S-methylisothiosemicarbazone complexes into albumin nanocarriers, creating albumin-bound Fe(III)-S-methyl-thiosemicarbazone (ALB-FeTc) nanoparticles via a novel UV-C lamp-assisted method. The nanoparticles were characterized using FTIR, UV-Vis, DLS and EDX-SEM. Cytotoxicity was evaluated in MCF-7 breast cancer cells and HUVEC cells using an MTT assay. Fluorescence microscopy and flow cytometry were employed to investigate the mechanism of cell death. The study demonstrated strong cytotoxicity of FeTcs against cancer cells, with enhanced effects observed for ALB-FeTcs. The ALB-FeTcs induced apoptosis selectively in cancer cells while sparing normal cells. These results suggest that ALB-FeTcs are promising candidates for breast cancer treatment. |
| Anahtar Kelimeler |
| breast cancer | Iron Thiosemicarbazone | MCF-7 | Nano albumin | Research&Development (R&D) |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Taibah University for Science |
| Dergi ISSN | 1658-3655 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2024 |
| Cilt No | 18 |
| Sayı | 1 |
| Sayfalar | 2375454 / 0 |
| Doi Numarası | 10.1080/16583655.2024.2375454 |
| Makale Linki | http://dx.doi.org/10.1080/16583655.2024.2375454 |
| Atıf Sayıları | |
| SCOPUS | 1 |
| Google Scholar | 1 |
