Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?

Ekinci, G.; DENİZ, Ömer; Tüfekci, E.; Timur, M. C.; Onmaz, A. C.; Günes, V.; Citil, M.; Keles; Hoven, R. V.D.

doi:10.24425/pjvs.2024.149367

Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?

Yazarlar (9)

G. Ekinci Erciyes Üniversitesi, Türkiye

Doç. Dr. Ömer DENİZ Kastamonu Üniversitesi, Türkiye

E. Tüfekci Erciyes Üniversitesi, Türkiye

M. C. Timur Head Office, Türkiye

A. C. Onmaz Erciyes Üniversitesi, Türkiye

V. Günes Erciyes Üniversitesi, Türkiye

M. Citil Erciyes Üniversitesi, Türkiye

Keles Erciyes Üniversitesi, Türkiye

R. V.D. Hoven University Equine Hospital, Avusturya

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Polish Journal of Veterinary Sciences (Q3)
Dergi ISSN	1505-1773 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	Türkçe	Basım Tarihi	09-2024
Cilt / Sayı / Sayfa	27 / 3 / 355–362	DOI	10.24425/pjvs.2024.149367
Makale Linki	http://dx.doi.org/10.24425/pjvs.2024.149367
UAK Araştırma Alanları	Veteriner İç Hastalıkları

Özet

Rhodococcus equi (R. equi) is a primary cause of pyogranulomatous pneumonia of foals between three weeks and five months of age. Early diagnosis of rhodococcal pneumonia has always been considered a preferable approach as it can lead to more successful treatment and better outcomes. Horse stud farms where the disease is common, neonatal foals are subjected to tests such as complete blood count and fibrinogen analysis at certain intervals. However, new biomarkers are needed in addition to blood count and fibrinogen measurement in this field for early diagnosis of diseases. Based on this need, in this study, the diagnostic importance of CL-11, SP-A, SP-D was investigated for the early diagnosis of pneumonia in foals naturally infected with R. equi. In a case-control design, fourteen 1-5 month-old foals with proven R. equi pyogranulomatous pneumonia and 10 healthy 1-5 month-old control foals were enrolled in this study. The median white blood cell count (WBC) and fibrinogen concentration in the case group were significantly higher than in the control group. The median CL-11, SP-A, and SP-D concentrations in the case group were also significantly higher than in the control group. However, there were overlaps in concentrations between groups for SP-A and SP-D. There was less overlap between the groups for the CL-11 concentration. The CL-11 assay was sufficiently accurate but over-diagnosed R. equi infection. The correlation plot between fibrinogen and CL-11 concentrations shows that this problem may be solved if CL-11 is used as the first biomarker and fibrinogen as the second check for those foals with CL-11 serum levels >0.8 and ≤1.5 ng/mL. As a result, in this study, it is recommended to use CL-11 together with fibrinogen to obtain more accurate results in diagnosing pyogranulomatous pneumonia caused by R. equi in foals on large horse stud farms.

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Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?

Dergi Adı	POLISH JOURNAL OF VETERINARY SCIENCES
Yayıncı	Polska Akademia Nauk
Açık Erişim	Hayır
ISSN	1505-1773
E-ISSN	2300-2557
CiteScore	1,5
SJR	0,320
SNIP	0,414

Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?

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