| Yazarlar |
Mustafa Kalaycı
Türkiye |
|
Ersan Çetinkaya
Antalya Bilim Üniversitesi, Türkiye |
|
Kenan Yiğit
Türkiye |
Dr. Öğr. Üyesi Mehmet Cem SABANER
Türkiye |
|
Reşat Duman
İzmir Bakırçay Üniversitesi, Türkiye |
|
Ahmet Rıfat Balık
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Özcan Erel
Ankara Yıldırım Beyazıt Üniversitesi, Türkiye |
| Özet |
| It was aimed to assess the role of thiol-disulphide homeostasis and ischemia-modified albumin (IMA) level in the development of diabetic macular edema (DME) in patients with diabetes mellitus type 2 (T2DM). Sixty-six study patients were divided into two groups. Group I included 43 patients with T2DM and DME, and Group 2 included 23 patients with T2DM without eye involvement. A novel colorimetric method was used to assess thiol-disulphide homeostasis. Between the two groups IMA, total anti-oxidant, and total oxidant levels were measured and compared. In Group 1, total and native thiol levels and disulphide levels were lower compared to Group 2 ( = .025, < .001 and = .013, respectively). Disulphide/native thiol, disulphide/total thiol ratios and native thiol/total thiol were similar between the groups. Total anti-oxidant level (TAL) reduced whereas total oxidant level (TOL) increased in Group 1 compared to Group 2 ( = .001, = .002, respectively). Albumin level decreased, whereas IMA level increased in Group 1 compared to Group 2 ( < .001 for both). The disruption in thiol/disulphide homeostasis, increased IMA and oxidative stress have an impact on the development of diabetic macular edema. |
| Anahtar Kelimeler |
| Thiols | albumin | diabetic eye disease | disulphide | reactive oxygen species |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CURRENT EYE RESEARCH |
| Dergi ISSN | 0271-3683 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2021 |
| Cilt No | 46 |
| Sayı | 5 |
| Sayfalar | 683 / 688 |
| Doi Numarası | 10.1080/02713683.2020.1818261 |
| Makale Linki | http://dx.doi.org/10.1080/02713683.2020.1818261 |
| Atıf Sayıları | |
| WoS | 5 |
