Ischemia-Modified Albumin Levels and Thiol-Disulphide Homeostasis in Diabetic Macular Edema in Patients with Diabetes Mellitus Type 2
Yazarlar (7)
Mustafa Kalaycı
Türkiye
Türkiye
Ersan Çetinkaya
Antalya Bilim Üniversitesi, Türkiye
Antalya Bilim Üniversitesi, Türkiye
Doç. Dr. Kenan Yiğit Türkiye
Mehmet Cem Sabaner
Reşat Duman İzmir Bakırçay Üniversitesi, Türkiye
Ahmet Rıfat Balık
Sağlık Bilimleri Üniversitesi, Türkiye
Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Özcan Erel Ankara Yıldırım Beyazıt Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CURRENT EYE RESEARCH (Q3) | ||
| Dergi ISSN | 0271-3683 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2021 |
| Cilt / Sayı / Sayfa | 46 / 5 / 683–688 | DOI | 10.1080/02713683.2020.1818261 |
| Makale Linki | http://dx.doi.org/10.1080/02713683.2020.1818261 | ||
| UAK Araştırma Alanları |
Göz Hastalıkları
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| Özet |
| It was aimed to assess the role of thiol-disulphide homeostasis and ischemia-modified albumin (IMA) level in the development of diabetic macular edema (DME) in patients with diabetes mellitus type 2 (T2DM). Sixty-six study patients were divided into two groups. Group I included 43 patients with T2DM and DME, and Group 2 included 23 patients with T2DM without eye involvement. A novel colorimetric method was used to assess thiol-disulphide homeostasis. Between the two groups IMA, total anti-oxidant, and total oxidant levels were measured and compared. In Group 1, total and native thiol levels and disulphide levels were lower compared to Group 2 ( = .025, < .001 and = .013, respectively). Disulphide/native thiol, disulphide/total thiol ratios and native thiol/total thiol were similar between the groups. Total anti-oxidant level (TAL) reduced whereas total oxidant level (TOL) increased in Group 1 compared to Group 2 ( = .001, = .002, respectively). Albumin level decreased, whereas IMA level increased in Group 1 compared to Group 2 ( < .001 for both). The disruption in thiol/disulphide homeostasis, increased IMA and oxidative stress have an impact on the development of diabetic macular edema. |
| Anahtar Kelimeler |
| Thiols | albumin | diabetic eye disease | disulphide | reactive oxygen species |
BM Sürdürülebilir Kalkınma Amaçları
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