| Yazarlar |
Elif Ertan Baydemir
Türkiye |
|
Neriman Efe Çalışkan
Türkiye |
Dr. Öğr. Üyesi Mehmet Cem SABANER
Türkiye |
|
Mustafa Doğan
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| The study aimed to evaluate the functional and anatomical results of patients treated with intravitreal ranibizumab (IVR) for neovascular age-related macular degeneration (n-AMD) but switched to intravitreal aflibercept (IVA) treatment due to insufficient response treatment. At least six doses of n-AMD were administered IVR to 33 patients who were switched to IVA treatment due to insufficient response and were included in the study. The patients were evaluated at the beginning of the IVR treatment during the transition to IVA treatment and at 6, 12, 18, 24, 30, 36, and 42 months of IVA treatment. After an average of 10.1 ± 5.04 IVR injections, the patients who were accepted as insufficient response were treated with IVA. The central macular thickness of the patients was evaluated at the beginning of the treatment, immediately before, and after the initiation of IVA treatment at 6, 12, 18, 24, 30, 36, 42 months. It was as follows: 325.21 ± 123.04, 351.42 ± 126.09, 284.81 ± 112.65, 296.68 ± 89.17, 282.61 ± 81.58, 292.27 ± 109, 92,269.75 ± 97.14, 267.50 ± 87.56, and 266.82 ± 88.35 μm. According to the best-corrected visual acuity (BCVA), it was initially 0.89 ± 0.65; 1.08 ± 0.53 during the transition to IVA; 0.91 ± 0.46 6 months after IVA; 12 1.14 ± 0.59; 0.94 ± 0.55 at 18; 1.07 ± 0.49 at 24; 1.15 ± 0.57 at 30; 1.06 ± 0.45 at 36, and 1.13 ± 0.46 LogMAR ( Logarithm of the Minimum Angle of Resolution) at the 42 month. In conclusion, in n-AMD patients with inadequate response to intravitreal ranibizumab or with relapse, and therefore, switched to aflibercept treatment, the anatomical improvement and sustainment were observed, however, functional recovery could not be achieved. |
| Anahtar Kelimeler |
| Aflibercept | age-related macular degeneration | ranibizumab | switch |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | NIGERIAN JOURNAL OF CLINICAL PRACTICE |
| Dergi ISSN | 1119-3077 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2021 |
| Cilt No | 24 |
| Sayı | 12 |
| Sayfalar | 1824 / 1827 |
| Doi Numarası | 10.4103/njcp.njcp_696_20 |
| Makale Linki | http://dx.doi.org/10.4103/njcp.njcp_696_20 |
| Atıf Sayıları | |
| WoS | 1 |
