| Yazarlar |
Dr. Öğr. Üyesi Mehmet Cem SABANER
Türkiye |
Mustafa Doğan
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
|
Müberra Akdoğan
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
|
Serdar Karadağ
Türkiye |
|
İsmail Umut Onur
Türkiye |
|
Ali İhsan Taşçı
Türkiye |
|
Fadime Ulviye Yiğit
Türkiye |
| Özet |
| To evaluate the effects of a single dose of oral 5-mg tadalafil on macular microcirculation as measured using optical coherence tomography (OCT) and angiography (OCTA) in healthy volunteers. Twenty-two healthy, middle-aged, sexually active, and male health care worker volunteers were included in this prospective study. All volunteers have a history of occasionally using off-label 5 mg tadalafil to enhance sexual performance. Superficial and deep capillary plexus vascular densities, foveal avascular zone parameters, outer retina, and choriocapillaris flow areas were performed using the OCTA, and subfoveal-choroidal thickness (CT) was performed by using the OCT. Measurements were performed preintake, 30 min, 1, 4, 24 h, 2, 3, 4, and 7 days after the intake of tadalafil off-label. Twenty-two eyes of 22 male volunteers were included in the study. The mean age was 37.16 ± 4.52 years. At 30 min, 1 h, and 4 h after intake, a statistically significant increase was observed in the choriocapillaris flow area and CT compared with preintake (, = 0.034 and < 0.001, respectively). This study showed that a single dose of oral 5-mg tadalafil causes an increase in choriocapillaris flow and CT. To evaluate the effects of tadalafil on the retina and choroid, an OCTA assessment may be helpful. |
| Anahtar Kelimeler |
| tadalafil,optical coherence tomography angiography,prospective study |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Ocular Pharmacology and Therapeutics |
| Dergi ISSN | 1080-7683 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2021 |
| Cilt No | 37 |
| Doi Numarası | 10.1089/jop.2020.0124 |
| Makale Linki | http://dx.doi.org/10.1089/jop.2020.0124 |
| Atıf Sayıları | |
| WoS | 1 |
