Evaluation of Retinal and Choroidal Microcirculation Alterations After a Single Dose of Oral 5-mg Tadalafil: A Prospective Pilot Optical Coherence Tomography Angiography Study
Yazarlar (7)
Mehmet Cem Sabaner
Prof. Dr. Mustafa Doğan Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Müberra Akdoğan Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
Serdar Karadağ
Türkiye
Türkiye
Doç. Dr. İsmail Umut Onur Türkiye
Prof. Dr. Ali İhsan Taşçı Türkiye
Fadime Ulviye Yiğit
Türkiye
Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (Q3) | ||
| Dergi ISSN | 1080-7683 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2021 |
| Cilt / Sayı / Sayfa | 37 / 7 / 421–429 | DOI | 10.1089/jop.2020.0124 |
| Makale Linki | http://dx.doi.org/10.1089/jop.2020.0124 | ||
| UAK Araştırma Alanları |
Göz Hastalıkları
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| Özet |
| To evaluate the effects of a single dose of oral 5-mg tadalafil on macular microcirculation as measured using optical coherence tomography (OCT) and angiography (OCTA) in healthy volunteers. Twenty-two healthy, middle-aged, sexually active, and male health care worker volunteers were included in this prospective study. All volunteers have a history of occasionally using off-label 5 mg tadalafil to enhance sexual performance. Superficial and deep capillary plexus vascular densities, foveal avascular zone parameters, outer retina, and choriocapillaris flow areas were performed using the OCTA, and subfoveal-choroidal thickness (CT) was performed by using the OCT. Measurements were performed preintake, 30 min, 1, 4, 24 h, 2, 3, 4, and 7 days after the intake of tadalafil off-label. Twenty-two eyes of 22 male volunteers were included in the study. The mean age was 37.16 ± 4.52 years. At 30 min, 1 h, and 4 h after intake, a statistically significant increase was observed in the choriocapillaris flow area and CT compared with preintake (, = 0.034 and < 0.001, respectively). This study showed that a single dose of oral 5-mg tadalafil causes an increase in choriocapillaris flow and CT. To evaluate the effects of tadalafil on the retina and choroid, an OCTA assessment may be helpful. |
| Anahtar Kelimeler |
| optical coherence tomography angiography | prospective study | tadalafil |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |