| Yazarlar |
Müberra Akdoğan
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
|
Mustafa Doğan
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
|
Selvihan Beysel
Türkiye |
|
Hamıdu Hamısı Gobeka
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Mehmet Cem SABANER
Türkiye |
|
Merve Oran
|
| Özet |
| To investigate changes in the retinal and optic disc (OD) morphology in prolactinoma patients without optical chiasmal compression and/or visual field defects using optical coherence tomography angiography (OCTA). In this cross-sectional imaging study, 16 consecutive prolactinoma patients (group 1, 32 eyes) and 15 age- and gender-matched healthy subjects (group 2, 30 eyes) underwent a thorough neuro-ophthalmological examination, which included testing for the presence of any intracranial compressive lesion that could cause optic neuropathy. Retinal morphological parameters, outer retinal and choriocapillaris flow areas, as well as OD vessel density (VD) and retinal nerve fiber layer (RNFL) thickness in for quadrants were then measured using OCTA. Mean age (p = 0.537) and gender (p = 0.385) of participants in groups 1 and 2 did not differ significantly. The mean BCVA for both groups was 0.00 ± 0.00 logMAR. Microadenomas made up the majority of prolactinomas (87.1 %). All retinal morphological parameters in deep capillary plexus (excluding foveal VD) differed significantly between groups 1 and 2 (whole: p < 0.001, parafoveal: p = 0.021, and perifoveal: p < 0.001). Peripapillary RNFL thickness in temporal (p < 0.001), nasal (p = 0.010), and inferior (p = 0.007) quadrants also differed significantly between the two groups. Foveal deep (r = -0.304, p = 0.035) and choriocapillaris flow (r = -0.511, p = 0.008) were negatively correlated with tumor size at diagnosis. Significant microvascular morphological changes, particularly in the deep retinal layer, as well as in the peripapillary RNFL thickness, were observed in prolactinoma patients. OCTA appears to be capable of detecting non-manifest circumpapillary and even intra-retinal microvascular changes even when there are no obvious signs of prolactinoma-related ocular complications caused by chiasmal compression. |
| Anahtar Kelimeler |
| Morphology | Optic disc | Optical coherence tomography angiography | Prolactinoma | Retinal microvasculature | Retinal nerve fiber layer |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | MICROVASCULAR RESEARCH |
| Dergi ISSN | 0026-2862 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2022 |
| Cilt No | 144 |
| Doi Numarası | 10.1016/j.mvr.2022.104424 |
| Makale Linki | http://dx.doi.org/10.1016/j.mvr.2022.104424 |
| Atıf Sayıları | |
| WoS | 1 |
