Morphological changes in retinochoroidal microvasculature after caffeinated versus decaffeinated coffee consumption
Yazarlar (4)
Prof. Dr. Mustafa Doğan Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Müberra Akdoğan Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
Mehmet Cem Sabaner
Doç. Dr. Hamıdu Hamısı Gobeka Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (Q3) | ||
| Dergi ISSN | 1572-1000 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2022 |
| Cilt / Sayı / Sayfa | 40 / 0 / – | DOI | 10.1016/j.pdpdt.2022.103138 |
| Makale Linki | http://dx.doi.org/10.1016/j.pdpdt.2022.103138 | ||
| UAK Araştırma Alanları |
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| Özet |
| To investigate changes in retinochoroidal microvascular morphology after caffeinated versus decaffeinated coffee consumption in age- and gender-matched healthy individuals using optical coherence tomography (OCT) and OCT angiography (OCTA). In this prospective, randomized clinical study, a staff member in charge of record keeping randomly assigned 48 healthy volunteers to two groups: caffeinated coffee consumers (24 eyes) and decaffeinated coffee consumers (24 eyes). Participants' ages and genders were recorded before consumption, and a comprehensive ophthalmologic exam was performed, followed by OCT and OCTA analyses before, 30 min, one, six, and 24 h after blindly consuming either of the coffees. Caffeinated and decaffeinated coffee consumers had mean ages of 23.45 ± 0.92 and 22.73 ± 1.13, respectively (p = 0.407). The following parameters changed significantly in caffeinated coffee consumers 30 min and 1 h post-consumption (pre-consumption versus 30 min versus one hour post-consumption; p < 0.05): a) parafoveal superficial capillary plexus vessel density (%): 54.45 versus 51.8 versus 51.92, b) parafoveal deep capillary plexus vessel density (%): 55.16 versus 52.45 versus 52.83, c) outer retinal flow area (%): 8.87 ± 1.91 versus 8.03 ± 1.88 versus 8.11 ± 1.93, d) choriocapillaris flow area (mm): 20.95 ± 0.98 versus 19.82 ± 1.20 a versus 19.62 ± 0.95, and e) sub-foveal choroidal thickness (µm): 295.06 ± 5.45 versus 277.08 ± 5.33 versus 260.71 ± 58.61. No significant differences in any OCT and OCTA parameters were found between consecutive measurements in decaffeinated coffee consumers (p > 0.05). Caffeinated coffee appears to transiently reduce parafoveal vessel density, capillary flow area, and sub-foveal choroidal thickness. Lack of these microvascular morphological changes in decaffeinated coffee suggests a potential caffeine-induced vasoconstrictive effect. |
| Anahtar Kelimeler |
| Caffeinated coffee | Capillary flow area | Decaffeinated coffee | Optic coherence tomography angiography | Spectral domain optic coherence tomography | Sub-foveal choroidal thickness | Vessel density |
BM Sürdürülebilir Kalkınma Amaçları
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