| Yazarlar |
Mustafa Doğan
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
|
Müberra Akdoğan
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Mehmet Cem SABANER
Türkiye |
|
Hamıdu Hamısı Gobeka
Afyonkarahisar Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| To investigate changes in retinochoroidal microvascular morphology after caffeinated versus decaffeinated coffee consumption in age- and gender-matched healthy individuals using optical coherence tomography (OCT) and OCT angiography (OCTA). In this prospective, randomized clinical study, a staff member in charge of record keeping randomly assigned 48 healthy volunteers to two groups: caffeinated coffee consumers (24 eyes) and decaffeinated coffee consumers (24 eyes). Participants' ages and genders were recorded before consumption, and a comprehensive ophthalmologic exam was performed, followed by OCT and OCTA analyses before, 30 min, one, six, and 24 h after blindly consuming either of the coffees. Caffeinated and decaffeinated coffee consumers had mean ages of 23.45 ± 0.92 and 22.73 ± 1.13, respectively (p = 0.407). The following parameters changed significantly in caffeinated coffee consumers 30 min and 1 h post-consumption (pre-consumption versus 30 min versus one hour post-consumption; p < 0.05): a) parafoveal superficial capillary plexus vessel density (%): 54.45 versus 51.8 versus 51.92, b) parafoveal deep capillary plexus vessel density (%): 55.16 versus 52.45 versus 52.83, c) outer retinal flow area (%): 8.87 ± 1.91 versus 8.03 ± 1.88 versus 8.11 ± 1.93, d) choriocapillaris flow area (mm): 20.95 ± 0.98 versus 19.82 ± 1.20 a versus 19.62 ± 0.95, and e) sub-foveal choroidal thickness (µm): 295.06 ± 5.45 versus 277.08 ± 5.33 versus 260.71 ± 58.61. No significant differences in any OCT and OCTA parameters were found between consecutive measurements in decaffeinated coffee consumers (p > 0.05). Caffeinated coffee appears to transiently reduce parafoveal vessel density, capillary flow area, and sub-foveal choroidal thickness. Lack of these microvascular morphological changes in decaffeinated coffee suggests a potential caffeine-induced vasoconstrictive effect. |
| Anahtar Kelimeler |
| Caffeinated coffee | Capillary flow area | Decaffeinated coffee | Optic coherence tomography angiography | Spectral domain optic coherence tomography | Sub-foveal choroidal thickness | Vessel density |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY |
| Dergi ISSN | 1572-1000 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2022 |
| Cilt No | 40 |
| Doi Numarası | 10.1016/j.pdpdt.2022.103138 |
| Makale Linki | http://dx.doi.org/10.1016/j.pdpdt.2022.103138 |
| Atıf Sayıları | |
| WoS | 3 |
