| Yazarlar (12) |
Alishba
University Of Karachi, Pakistan |
|
Irfan Ali
University Of Karachi, Pakistan |
|
Shehryar Hameed
University Of Karachi, Pakistan |
|
Khalid Mohammed Khan
University Of Karachi, Pakistan |
|
Uzma Salar
University Of Karachi, Pakistan |
|
Muhammad Taha
Imam Abdulrahman Bin Faisal University, Suudi Arabistan |
|
Nastaran Sadeghian
Bartin Üniversitesi, Türkiye |
|
Parham Taslimi
Bartin Üniversitesi, Türkiye |
|
Burak Tuzun
Cumhuriyet Üniversitesi, Türkiye |
Doç. Dr. Dilşad ÖZERKAN
Kastamonu Üniversitesi, Türkiye |
|
Huri Dedeakayogullari
Biruni Üniversitesi, Türkiye |
|
Engin Ulukaya
Istanbul Üniversitesi, Türkiye |
| Özet |
| A series of benzothiazine derivatives (1–17) were synthesized via an intermolecular cyclocondensation reaction involving 2-aminothiophenol (i) and substituted phenacyl bromide (ii). Structural elucidation of these synthetic derivatives utilized EI–MS, HR-EIMS, 1H NMR, and 13C NMR spectroscopic techniques. The synthesized analogs were evaluated against key enzyme targets (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase (α-Glu)) and tested for cytotoxicity against various cancer cell lines. Six compounds were selected based on their inhibition profiles, exhibiting significant inhibitory potential against enzymes. In silico studies corroborated the observed inhibitory activities, aligning closely with experimental outcomes. Additionally, an ADME/T study provided insights into pharmacokinetic and safety profiles, identifying promising candidates for future drug development efforts. |
| Anahtar Kelimeler |
| ADME/T | Alzheimer's disease | Cancer | Diabetes | Synthesis |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Chemistryselect |
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2024 |
| Cilt No | 9 |
| Sayı | 38 |
| Doi Numarası | 10.1002/slct.202404087 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202404087 |
| Atıf Sayıları | |
| WoS | 6 |
| SCOPUS | 8 |
| Google Scholar | 9 |
