| Yazarlar |
Alishba A
|
|
İrfan Ali
|
|
Shehryar Hameed
|
|
Khalid Mohammed Khan
|
|
Uzma Salar
|
|
Muhammed Taha
|
|
Nastaran Sadeghıan
Bartın Üniversitesi, Türkiye |
|
Parham Taslımı
Bartın Üniversitesi, Türkiye |
|
Burak Tüzün
Sivas Cumhuriyet Üniversitesi, Türkiye |
Doç. Dr. Dilşad ÖZERKAN
Kastamonu Üniversitesi, Türkiye |
|
Huri Dedeakayoğulları
Biruni Üniversitesi, Türkiye |
|
Engin Ulukaya
İstinye Üniversitesi, Türkiye |
| Özet |
| A series of benzothiazine derivatives (1–17) were synthesized via an intermolecular cyclocondensation reaction involving 2-aminothiophenol (i) and substituted phenacyl bromide (ii). Structural elucidation of these synthetic derivatives utilized EI–MS, HR-EIMS, 1H NMR, and 13C NMR spectroscopic techniques. The synthesized analogs were evaluated against key enzyme targets (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase (α-Glu)) and tested for cytotoxicity against various cancer cell lines. Six compounds were selected based on their inhibition profiles, exhibiting significant inhibitory potential against enzymes. In silico studies corroborated the observed inhibitory activities, aligning closely with experimental outcomes. Additionally, an ADME/T study provided insights into pharmacokinetic and safety profiles, identifying promising candidates for future drug development efforts. |
| Anahtar Kelimeler |
| ADME/T | Alzheimer's disease | Cancer | Diabetes | Synthesis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ChemistrySelect |
| Dergi ISSN | 2365-6549 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2024 |
| Cilt No | 9 |
| Sayı | 38 |
| Doi Numarası | 10.1002/slct.202404087 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202404087 |
| Atıf Sayıları |
