Exploring Benzo[b][1,4]Thiazine Derivatives: Multitarget Inhibition, Structure–Activity Relationship, Molecular Docking, and ADMET Analysis
Yazarlar (12)
Alishba
University Of Karachi, Pakistan
University Of Karachi, Pakistan
Irfan Ali University Of Karachi, Pakistan
Shehryar Hameed University Of Karachi, Pakistan
Khalid Mohammed Khan
University Of Karachi, Pakistan
University Of Karachi, Pakistan
Uzma Salar
University Of Karachi, Pakistan
University Of Karachi, Pakistan
Muhammad Taha
Imam Abdulrahman Bin Faisal University, Suudi Arabistan
Imam Abdulrahman Bin Faisal University, Suudi Arabistan
Nastaran Sadeghian Bartin Üniversitesi, Türkiye
Doç. Dr. Parham Taslimi Bartin Üniversitesi, Türkiye
Prof. Dr. Burak Tuzun Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Huri Dedeakayogullari
Biruni Üniversitesi, Türkiye
Biruni Üniversitesi, Türkiye
Engin Ulukaya Istanbul Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2024 |
| Kabul Tarihi | 21-09-2024 | Yayınlanma Tarihi | 01-10-2024 |
| Cilt / Sayı / Sayfa | 9 / 38 / – | DOI | 10.1002/slct.202404087 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202404087 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| A series of benzothiazine derivatives (1–17) were synthesized via an intermolecular cyclocondensation reaction involving 2‐aminothiophenol (i) and substituted phenacyl bromide (ii). Structural elucidation of these synthetic derivatives utilized EI–MS, HR‐EIMS, 1H NMR, and 13C NMR spectroscopic techniques. The synthesized analogs were evaluated against key enzyme targets (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glucosidase (α‐Glu)) and tested for cytotoxicity against various cancer cell lines. Six compounds were selected based on their inhibition profiles, exhibiting significant inhibitory potential against enzymes. In silico studies corroborated the observed inhibitory activities, aligning closely with experimental outcomes. Additionally, an ADME/T study provided insights into pharmacokinetic and safety profiles, identifying promising candidates for future drug development efforts. |
| Anahtar Kelimeler |
| ADME/T | Alzheimer's disease | Cancer | Diabetes | Synthesis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 13 |
| Google Scholar | 14 |