Bisphenol AF Caused Reproductive Toxicity in Rats and Cineole Co-Treatment Exhibited Protective Effect
Yazarlar (8)
Dr. Öğr. Üyesi Ahmet Uyar Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Mustafa Cellat Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Özgür Kanat Necmettin Erbakan Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Tuncer Kutlu Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Mehmet Zeki Yılmaz Deveci Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. İlker Yavaş Mustafa Kemal Üniversitesi, Türkiye
Müslüm Kuzu Karabük Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Reproductive Sciences (Q2) | ||
| Dergi ISSN | 1933-7191 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2024 |
| Kabul Tarihi | 08-08-2024 | Yayınlanma Tarihi | 19-08-2024 |
| Cilt / Sayı / Sayfa | 31 / 11 / 3462–3474 | DOI | 10.1007/s43032-024-01677-7 |
| Makale Linki | https://doi.org/10.1007/s43032-024-01677-7 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| Bisphenol AF (BPAF) is increasingly used and now found in products intended for human consumption. The protective effect of 1,8-cineole (CIN) against BPAF-induced reproductive toxicity was investigated. Four groups were created, with each group consisting of eight rats: control, BPAF (200 mg/kg), CIN (200 mg/kg), and BPAF + CIN groups. The results demonstrated that the BPAF group exhibited a decline in testosterone levels and a decrease in sperm parameters compared with the control. Additionally, higher levels of MDA were observed, along with lower levels of GSH and GPx activity. CAT activity also decreased slightly. Tnf-α, Nf-κB levels were significantly higher, and caspase-3 expression was elevated, while PCNA expression decreased. BPAF significantly increased tissue degeneration compared with the control. However, the BPAF + CIN group showed statistically significant improvements in … |
| Anahtar Kelimeler |
| Endocrine disruptor | Herbal medicine | Infertility | Natural antioxidant | Oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 6 |
| Google Scholar | 6 |