| Yazarlar |
Mustafa Cellat
University of Hatay Mustafa Kemal, Türkiye |
|
İbrahim Ozan Tekeli
University of Hatay Mustafa Kemal, Türkiye |
|
Erdinç Türk
University of Hatay Mustafa Kemal, Türkiye |
|
Tuba Aydin
Ağrı İbrahim Çeçen University, Türkiye |
|
Ahmet Uyar
University of Hatay Mustafa Kemal, Türkiye |
|
Cafer Tayer İşler
University of Hatay Mustafa Kemal, Türkiye |
|
İshak Gökçek
University of Hatay Mustafa Kemal, Türkiye |
Dr. Öğr. Üyesi Muhammed ETYEMEZ
Kastamonu Üniversitesi |
|
Mehmet Güvenç
University of Hatay Mustafa Kemal, Türkiye |
| Özet |
| Increased pro-inflammatory cytokines and oxidative stress contribute to the pathophysiology of ulcerative colitis (UC). is a plant with antioxidant and anti-inflammatory properties. We investigated the effect of an ethanolic extract of on an experimental UC model created using acetic acid. Rats were divided into four groups of eight: group 1, control; group 2, 3% acetic acid group; group 3, 100 mg/kg sulfasalazine + 3% acetic acid group; group 4, 400 mg/kg + 3% acetic acid. and sulfasalazine were administered by oral gavage and 3% acetic acid was administered per rectum. We found that treatment decreased colon malondialdehyde, tumor necrosis factor-α, interleukin-1 beta and nuclear factor kappa B levels; it increased reduced glutathione, nuclear factor erythroid 2-related factor 2, heme oxygenase-1 and kelch-like ECH-associated protein 1 levels and glutathione peroxidase enzyme activity. Group 1 colon exhibited normal histological structure. Slight inflammatory cell infiltration and edema and insignificant slight erosion in crypts were detected in colon tissues of group 4. We found that reduced oxidative stress and inflammation, which was protective against UC by inducing the Nrf-2/Keap-1/HO-1 pathway in the colon. |
| Anahtar Kelimeler |
| Acetic acid | Inula viscosa | antioxidant | inflammation | rats | ulcerative colitis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayımlanan tam makale |
| Dergi Adı | Biotechnic & histochemistry : official publication of the Biological Stain Commission |
| Dergi ISSN | 1473-7760 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2023 |
| Cilt No | 98 |
| Sayfalar | 255 / 266 |
| Doi Numarası | 10.1080/10520295.2023.2176923 |
| Atıf Sayıları |
