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Serum kisspeptin levels in deep-infiltrating, ovarian, and superficial endometriosis A prospective observational study   
Yazarlar
Mesut Onal
Pervin Karli
Öğr. Gör. Dr. Ayşe ÖZDEMİR
Kastamonu Üniversitesi
Adem Kocaman
Yunus Katirci
Gulnur Coban
Gulen Kubra Nakisli
Yesim Civil
Bahattin Avci
Özet
The diagnosis of endometriosis may delay for many years due to non-deterministic symptoms and avoiding surgical interventions. Kisspeptins are hormones that interact with endometrial tissue to limit invasions during placentation and various cancers and are suggested to be also associated with endometriosis. This study evaluated if serum kisspeptin levels are associated with the invasion depth in endometriosis. Forty patients between 18 and 45 years of age and admitted to a tertiary-care Obstetrics and Gynecology Department between 2020 and 2021 with a diagnosis of endometriosis, and 40 patients without endometrioma were included in the study. Demographic, obstetric, clinical, and biochemical characteristics were evaluated in patients with superficial (SE) and deep infiltrating (DIE) endometriosis and healthy controls. Twenty patients (50%) had SE, 14 (35%) had DIE, and 22 (55%) had endometrioma in the patient group. Fertility rates were higher among controls, but similar between patients with SE and DIE. CA125 levels were significantly higher in the DIE group. SE and DIE groups had similar kisspeptin values, significantly higher than controls. CA125 and kisspeptin levels were not correlated in study groups. Serum kisspeptin levels were significantly different between endometriosis patients and healthy controls. However, kisspeptin levels were unable to differentiate endometriosis severity. Our results suggest that kisspeptins might play a role in the pathogenesis of endometriosis, which needs further assessment in more comprehensive studies.
Anahtar Kelimeler
deep infiltrating | endometrioma | endometriosis | kisspeptin | pathogenesis | superficial
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı MEDICINE
Dergi ISSN 0025-7974
Makale Dili İngilizce
Basım Tarihi 01-2022
Cilt No 101
Sayı 45
Doi Numarası 10.1097/MD.0000000000031529