| Yazarlar |
Murat Akcay
|
Öğr. Gör. Dr. Ayşe ÖZDEMİR
Kastamonu Üniversitesi |
| Özet |
| The present study evaluates the arterial stiffness and hemodynamic parameters in patients with a supraphysiological estrogen level due to in vitro fertilization (IVF) with controlled ovarian hyperstimulation (COH). A total of 82 female patients aged 24-45 years were included. Their arterial stiffness parameters were analyzed before and after the appropriate COH protocol involving arteriography using Mobil-O-Graph NG (IEM GmbH, Stolberg, Germany) 24-hour ambulatory blood pressure monitor. Systolic, diastolic, mean, central systolic, and diastolic blood pressures, as well as peripheral vascular resistance, were significantly lower after COH therapy (p=0.001, 0.002, <0.001, <0.001, 0.040, and <0.001, respectively). In contrast, there was no statistically significant difference observed in heart rate, pulse pressure, or cardiac output. The pulse wave velocity measurement was significantly lower after COH than the baseline levels [5.3 m/s (4.5-6.9 m/s) versus 5.4 m/s (4.7-7.3 m/s,); p<0.001], but the augmentation index was not significantly different [28% (4%-41%) versus 29% (5%-43%); p=0.090]. When the patients were grouped according to the occurrence of a pregnancy after IVF therapy, all parameters were not different between the pregnancy (+) and pregnancy (-) patients (p>0.05). Arterial stiffness and hemodynamic parameters significantly decreased in IVF patients who underwent COH therapy. The long-term clinical significance of this short-term effect should be investigated with prospective studies. There was no significant difference in all parameters before and after COH when the pregnancy (+) and pregnancy (-) patients were compared. |
| Anahtar Kelimeler |
| arterial stiffness | controlled ovarian hyperstimulation | supraphysiological estrogen | in vitro fertilization | pulse wave velocity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | ANATOLIAN JOURNAL OF CARDIOLOGY |
| Dergi ISSN | 2149-2263 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2021 |
| Cilt No | 25 |
| Sayı | 5 |
| Sayfalar | 346 / 351 |
| Doi Numarası | 10.14744/AnatolJCardiol.2020.38890 |
| Atıf Sayıları | |
| WoS | 1 |
