| Yazarlar |
Arif Kokcu
|
|
Emel Kurtoglu
|
|
Handan Celik
|
|
Migraci Tosun
|
|
Erdal Malatyalioglu
|
Öğr. Gör. Dr. Ayşe ÖZDEMİR
Kastamonu Üniversitesi |
| Özet |
| The study aimed to evaluate changes in hematologic parameters, including white blood cell, platelet count, platelet indices, the platelet to lymphocyte and neutrophil to lymphocyte ratios in patients with early and advanced stages of epithelial ovarian cancers. The study included 100 patients with epithelial ovarian cancer who underwent primary staging exploratory laparotomy. Preoperative hematologic parameters, tumor histopathologic type, grade, stage and serum CA-125 levels were retrospectively analyzed. These parameters were compared between the patients with early (stage I-II) and advanced (stage III-IV) ovarian cancer. White blood cell count and platelet indices, including mean platelet volume, platelet distribution width and platelet crit did not show a statistically significant difference between groups with early and advanced ovarian cancer. However, the neutrophil to lymphocyte ratio, platelet count, the platelet to lymphocyte ratio and CA-125 level showed a statistically significant difference between the two groups (p<0.05, p<0.01, p<0.001, p<0.01 respectively). It was found that the neutrophil to lymphocyte ratio, platelet count and the platelet to lymphocyte ratio increased with the increasing stage of ovarian cancer. Furthermore, it was seen that the platelet to lymphocyte ratio is an independent prognostic factor related to the stage of epithelial ovarian cancer. |
| Anahtar Kelimeler |
| Epithelial ovarian cancer | neutrophil to lymphocyte ratio | prognostic factor |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayımlanan tam makale |
| Dergi Adı | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION |
| Dergi ISSN | 1513-7368 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2014 |
| Cilt No | 15 |
| Sayı | 22 |
| Sayfalar | 9781 / 9784 |
| Doi Numarası | 10.7314/APJCP.2014.15.22.9781 |
| Atıf Sayıları | |
| WoS | 40 |
