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Exploring improved strategies for therapeutic studies and biological activities of novel zinc and indium phthalocyanines   
Yazarlar
Kevser Celep
Yıldız Teknik Üniversitesi, Turkey
Göknur Yaşa Atmaca
Yıldız Teknik Üniversitesi, Turkey
Pelin Demir Aydoğmuş
Yıldız Teknik Üniversitesi, Turkey
Kumsal Eroğlu
Yıldız Teknik Üniversitesi, Turkey
Ömer Tahir Günkara
Yıldız Teknik Üniversitesi, Turkey
Dr. Öğr. Üyesi Gülay GİRAY Dr. Öğr. Üyesi Gülay GİRAY
Kastamonu Üniversitesi, Türkiye
Gülşah Tollu
Mersin Üniversitesi, Turkey
Sadin Özdemir
Mersin Üniversitesi, Turkey
Ali Erdoğmuş
Yıldız Teknik Üniversitesi, Turkey
Özet
This study investigates novel zinc and indium phthalocyanines with Schiff base and sulphur moieties, focusing on their potential for cancer therapy and antimicrobial applications. It explores the effectiveness of photochemical and sono-photochemical methods to enhance singlet oxygen production, which is crucial for photodynamic therapy. The synthesized complexes in this study demonstrated high singlet oxygen quantum yields, with D3 (ZnPc) and D4 (InPc) showing ΦΔPDT values of 0.71 and 0.75, and ΦΔSPDT values of 0.91 and 0.94, respectively. Furthermore, the evaluation for biological properties revealed that both D3 and D4 exhibit significant antidiabetic properties, DPPH radical scavenging activity, DNA cleavage, antimicrobial activity, biofilm inhibition, and microbial cell viability impacts, both with and without photodynamic therapy. Notably, D3 and D4 achieved antimicrobial cell viability inhibition rates of 84.67 ± 4.67% and 98.32 ± 5.96%, respectively, showcasing their effectiveness in photodynamic antimicrobial therapy. Overall, the study highlights the potential of these phthalocyanine complexes as advanced photosensitizers, with strong singlet oxygen generation and promising biological activities, paving the way for future therapeutic applications.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Dalton Transactions
Dergi ISSN 1477-9226
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 01-2024
Cilt No 53
Sayı 1
Sayfalar 17381 / 17393
Doi Numarası 10.1039/d4dt02261k