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Synthesis, spectroscopic characterization, DFT studies and antioxidant activity of new 5-substituted isatin/thiosemicarbazones  
Yazarlar
Doç. Dr. Halit MUĞLU
Kastamonu Üniversitesi, Türkiye
Özet
A new series of thiosemicarbazone derivatives (1–8) were prepared and elucidated by FT-IR, 1H NMR, and 13C NMR spectroscopic methods and elemental analysis. In this study, in which the antiradical activities of 1,1-diphenyl-2-picrylhydrazil (DPPH) were investigated, ascorbic acid was used as a reference antioxidant. Also, density functional theory (DFT) calculations were employed to investigate the structural and electronic properties of compounds, and the obtained data were utilized to elucidate antioxidant activity. In summary, the half maximal inhibitory concentration (IC50) values were calculated and had lower antioxidant activity than the standard ascorbic acid.
Anahtar Kelimeler
DFT calculation | DPPH | Isatin | Spectroscopic methods | Thiosemicarbazones
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Journal of Molecular Structure
Dergi ISSN 0022-2860
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 02-2025
Cilt No 1322
Sayı 1
Doi Numarası 10.1016/j.molstruc.2024.140406