| Yazarlar (8) |
İlknur Keskin
Türkiye |
|
Seda Karabulut
Türkiye |
|
Arife Ahsen Kaplan
Türkiye |
|
Murat Alagöz
Türkiye |
|
Muhterem Akdeniz
|
Doç. Dr. Kıymet Kübra TÜFEKCİ
Kastamonu Üniversitesi, Türkiye |
|
Devra Davis
|
|
Süleyman Kaplan
Ondokuz Mayıs Üniversitesi, Türkiye |
| Özet |
| The use of technologies that produce and emit electromagnetic fields (EMF) is growing exponentially worldwide. The biological effects of EMF-emitting equipment, such as mobile phones and other wireless devices, have been studied in the last decade using in vitro and in vivo methods. Infertility is a growing health problem, and nearly half of cases are because of male-factor. This study investigated the direct in vitro effects of 900 MHz radiation exposure on sperm parameters, genetic status, apoptotic markers, and the PI3K/AKT signaling pathway in healthy normozoospermic men. Semen samples were divided into four groups, two control (30 min and 1 h) and two EMF exposure (30 min and 1 h). Sperm parameters (motility, progressive motility, acrosomal index, morphology), genetic status (DNA fragmentation and chromatin integrity), apoptotic markers (cytokine-c and caspase-3 expression) and the PI3K/AKT signaling pathway (phosphoinoitide 3-kinase-PI3K- and phosphorylated AKT- p-AKT-) were analysed. Sperm motility were significantly reduced in 30 min EMF exposure while a significant increase in the expression of p-AKT were observed in 1 h EMF exposure group. An increased vacuolisation, acrosomal defect, extension of subacrosomal space, uncondensed chromatin structure, apoptotic signs and disrupted axoneme were observed in both EMF groups which were not observed in the control group. Other sperm parameters (morphology and acrosomal index), genetic status, apoptotic markers and the PI3K expression rates had no significant change. |
| Anahtar Kelimeler |
| Apoptosis | Male fertility | PI3K | Sperm parameters |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Reproductive Toxicology |
| Dergi ISSN | 0890-6238 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2024 |
| Cilt No | 130 |
| Sayfalar | 108744 / 0 |
| Doi Numarası | 10.1016/j.reprotox.2024.108744 |
| Makale Linki | http://dx.doi.org/10.1016/j.reprotox.2024.108744 |
| Atıf Sayıları |
