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The Effects of Curcumin on Hyperglycaemia-Induced Optic Nerve Damage in Wistar Albino Rats: An Electron Microscopic and Stereological Study    
Yazarlar (5)
İzem Olcay Şahin
Muzaffer Başak Tunalı
Türkiye
Abit Aktaş
İstanbul Üniversitesi-Cerrahpaşa, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Doç. Dr. Kıymet Kübra TÜFEKCİ
Kastamonu Üniversitesi, Türkiye
Süleyman Kaplan
Ondokuz Mayıs Üniversitesi, Türkiye
Devamını Göster
Özet
This study examined potential therapeutic or preventive benefits of curcumin on the damage caused by hyperglycemia to the optic nerves of diabetic rats. Forty-two Wistar female albino rats were allocated to 7 groups at random, with 6 rats in each group. The rats of control group (Cont) were not subjected to any treatment. Corn oil (1ml/kg) was applied to Sham group (Sham) via gavage for 14 days. For the diabetes model, rats of four groups were given one dose of 50 mg/kg streptozotocin (STZ) intraperitoneally. The diabetic animals received gavage treatments of 30 mg/kg curcumin in corn oil for 14 days. Curcumin and STZ were applied simultaneously in the diabetes-curcumin 3 (DC3) group. Curcumin was given to the diabetes-curcumin 1 (DC1) group 7 days and to the diabetes-curcumin 2 (DC2) group 21 days after the diabetes model was created. The curcumin (Cur) group received just curcumin (30 mg/kg) in corn oil for 14 days). Histopathological analysis was performed on semithin (500 nm) sections. In thin (70 nm) sections, quantitative parameters of optic nerve were examined by stereological methods. Diabetes significantly reduced the number of myelinated axons compared to the control group (p< 0.05). The DC2 group compared to the diabetes group had higher myelinated axons number (p< 0.05). The effect of curcumin application on optic nerve of diabetic animals did not show any difference in other parameters. Qualitative analysis showed morphological changes in optic nerve and protective effect of curcumin in ultrastructural analysis, suggesting its potential therapeutic role against diabetic optic nerve damage. The electron …
Anahtar Kelimeler
Diabetes mellitus | Optic nerve | Stereology | Wistar albino rats | Curcumin
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı The Pakistan Veterinary Journal
Dergi ISSN 0253-8318 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili Türkçe
Basım Tarihi 01-2024
Cilt No 44
Sayı 4
Sayfalar 1161 / 1168
Doi Numarası 10.29261/pakvetj/2024.270
Makale Linki http://dx.doi.org/10.29261/pakvetj/2024.270