| Yazarlar |
Gökçe Erdemir
Istanbul Üniversitesi, Turkey |
|
Ferdane DANIŞMAN-KALINDEMIRTAŞ
Erzincan Binali Yıldırım Üniversitesi, Turkey |
|
İshak Afşin KARIPER
Erciyes Üniversitesi, Turkey |
|
Dürdane Serap KURUCA
İstanbul Atlas Üniversitesi, Turkey |
Doç. Dr. Dilşad ÖZERKAN
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Colorectal cancer (CRC) is a leading cause of morbidity and death worldwide. As current cancer drugs are ineffective, new solutions are being sought in other fields, including nanoscience. Similarly, silver nanoparticles play an important role in the pharmaceutical industry as they act as anti-cancer agents with less harmful effects and are usually 1 to 100 nm in size. Selenic acid (SA) and pyruvic acid (PA) are involved in various metabolic pathways in cancer. For this reason, we decided to detect their influence on colorectal cancer using silver-based (Ag) nanocarriers. DLS, Zetasizer, SEM and UV-Vis analyses were used to characterize AgSA and AgPA. A UV spectrophotometer was used to analyze the release of the NPs. MTT analyses were used to measure the viability of HCT116 and HUVEC cells, and IC50 values were calculated using GraphPad Prism. The indicated dosage and particle size of AgSA NPs proved to be suitable for cytotoxicity. Moreover, injection of these nanoparticles into non-cancer cells proved safe due to their minimal toxicity. In contrast, the AgPA NPs have no cytotoxicity and induce proliferation of HCT116 cells. Finally, only the synthesised AgSA nanoparticles could be used for advanced cancer therapy, which is both inexpensive and has minimal side effects. |
| Anahtar Kelimeler |
| Colorectal cancer | Cytotoxicity | Pyruvic acid | Selenic acid | Silver nanoparticle |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Fluorescence |
| Dergi ISSN | 1053-0509 |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2024 |
| Cilt No | 34 |
| Sayı | 3 |
| Sayfalar | 1025 / 1037 |
| Doi Numarası | 10.1007/s10895-023-03339-4 |
| Atıf Sayıları |
