Comparison of Selenic Acid and Pyruvic Acid-Loaded Silver Nanocarriers Impact on Colorectal Cancer Viability
Yazarlar (5)
Gökçe Erdemir
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Ferdane Danışman-Kalındemırtaş Erzincan Binali Yıldırım Üniversitesi, Türkiye
Prof. Dr. İshak Afşin Karıper Erciyes Üniversitesi, Türkiye
Dürdane Serap Kuruca İstanbul Atlas Üniversitesi, Türkiye
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Fluorescence (Q2) | ||
| Dergi ISSN | 1053-0509 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2024 |
| Cilt / Sayı / Sayfa | 34 / 3 / 1025–1037 | DOI | 10.1007/s10895-023-03339-4 |
| Makale Linki | http://dx.doi.org/10.1007/s10895-023-03339-4 | ||
| Özet |
| Colorectal cancer (CRC) is a leading cause of morbidity and death worldwide. As current cancer drugs are ineffective, new solutions are being sought in other fields, including nanoscience. Similarly, silver nanoparticles play an important role in the pharmaceutical industry as they act as anti-cancer agents with less harmful effects and are usually 1 to 100 nm in size. Selenic acid (SA) and pyruvic acid (PA) are involved in various metabolic pathways in cancer. For this reason, we decided to detect their influence on colorectal cancer using silver-based (Ag) nanocarriers. DLS, Zetasizer, SEM and UV-Vis analyses were used to characterize AgSA and AgPA. A UV spectrophotometer was used to analyze the release of the NPs. MTT analyses were used to measure the viability of HCT116 and HUVEC cells, and IC50 values were calculated using GraphPad Prism. The indicated dosage and particle size of AgSA NPs … |
| Anahtar Kelimeler |
| Colorectal cancer | Cytotoxicity | Pyruvic acid | Selenic acid | Silver nanoparticle |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |