A portable biosensor for simultaneous diagnosis of TNF-α and IL-1β in saliva biomarkers using twin electronic devices
Yazarlar (6)
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, İran
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN Kastamonu Üniversitesi, Türkiye
Motahareh Dehghandar
Islamic Azad University, Science And Research Branch, İran
Islamic Azad University, Science And Research Branch, İran
Sara Shahriari
Islamic Azad University, Central Tehran Branch, İran
Islamic Azad University, Central Tehran Branch, İran
Parisa Latifi
Islamic Azad University, Tehran Medical Branch, İran
Islamic Azad University, Tehran Medical Branch, İran
Samira Mohammadi
Islamic Azad University, İran
Islamic Azad University, İran
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Journal of Sensors and Sensor Systems | ||
| Dergi ISSN | 2194-8771 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | ESCI, SCOPUS, Curation, Non-Essential Science Content, Reference Master, Sophia | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 13 / 2 / 245–261 | DOI | 10.5194/jsss-13-245-2024 |
| Makale Linki | https://jsss.copernicus.org/articles/13/245/2024/ | ||
| UAK Araştırma Alanları |
Fiziksel Kimya
|
||
| Özet |
| For several types of diseases, such as meningitis or oral cancers, the simultaneous diagnosis and measurement of the tumour necrosis factor (TNF-) and interleukin-1 (IL-1) immune-modulating biomarkers, with respect to both quality and quantity, are important. For example, although meningitis is generally caused by bacteria or viruses, the differences between viral and bacterial structures can be problematic for medical doctors to distinguish, as laboratory data assay techniques for the two are often similar and can overlap; moreover, in such cases, distinguishing between virial and bacterial structures is especially problematic following the use of antibiotics prior to cerebrospinal fluid testing. In this work, we simultaneously evaluated the precision of both TNF- and IL-1 for the diagnosis of disease. In this research area, twin electrochemical biosensors have been designed as strong tools for the wide-spectrum assessment of biomarkers, thereby aiding in the screening, diagnosis, and monitoring of pathologies and treatment performance. In this research, we present a sensor platform model that can enable one to detect biomarkers quickly; specifically, this platform can be used to detect TNF- and IL-1 in saliva. A two-peptide recognition element was created and designed using the phage display technique. This element selectively binds TNF- and IL-1 to an electronics-based metal–oxide–semiconductor field-effect transistor/electrolyte-gated transistor (MOSFET/GT) bio-detector device and label-free biosensor, allowing for the rapid, simultaneous detection of both biomarkers. These bio-affinity recognition methods have … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 3 |