| Yazarlar (5) |
Ender Deniz Asmaz
Ankara Medipol Üniversitesi, Türkiye |
|
Hikmet Taner Teker
Ankara Medipol Üniversitesi, Türkiye |
|
Zeynep Tuğçe Sertkaya
Ankara Medipol Üniversitesi, Türkiye |
|
Taha Ceylani
Muş Alparslan Üniversitesi, Türkiye |
Arş. Gör. Dr. Aysun İNAN GENÇ
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Blood plasma therapy, a new treatment method to eliminate the damage and deterioration caused by aging in many organ systems, has attracted increasing attention. The digestive tract, which cooperates with many different systems, has strong effects on our health. In the present study, the effects of plasma therapy on the ileum of elderly rats were investigated. Wistar rats (n = 7; 12-15 months old) were given pooled plasma collected from middle-age rats (6 months, n =28) (for 30 days, 0.3 ml daily, intravenously into the tail vein). At the end of the experiment, villus height, crypt depth, total mucosal thickness and surface absorption area were evaluated. In addition, the effects of IgA, which plays a role in the digestive system's defense against microorganisms, were examined. Both the cell proliferation intensity and proliferation index were evaluated in crypt cells. An increase was determined in all morphological parameters in the experimental group. Similarly, plasma application decreased IgA expression and numbers in the experimental groups. Contrarily, cell proliferation parameters showed a significant increase in the experimental groups' crypt cells. Therefore, we found that the treatment supports the digestive system in terms of both nutrient utilization and absorption-related parameters and has a protective effect on intestinal immune system parameters. |
| Anahtar Kelimeler |
| IgA | Ileum | Blood plasma treatment | Ki-67 | Wistar rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Histochemistry and Cell Biology |
| Dergi ISSN | 1432-119X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCOPUS |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2024 |
| Cilt No | 163 |
| Sayı | 17 |
| Doi Numarası | 10.1007/s00418-024-02344-3 |
| Makale Linki | https://doi.org/10.1007/s00418-024-02344-3 |
| Atıf Sayıları | |
| WoS | 2 |
| Google Scholar | 3 |
