Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.
Yazarlar (6)
Doç. Dr. Ayşe GÜNEŞ BAYIR Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Abdürrahim Koçyiğit Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Eray Metin Güler Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Mehmet Gültekin Bilgin
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Dr. Öğr. Üyesi İlyas Samet Ergün Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Agnes Dadak
Veterinarmedizinische Universitat Wien, Avusturya
Veterinarmedizinische Universitat Wien, Avusturya
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular and Cellular Biochemistry (Q4) | ||
| Dergi ISSN | 0300-8177 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2018 |
| Cilt / Sayı / Sayfa | 448 / 1 / 237–249 | DOI | 10.1007/s11010-018-3329-5 |
| Makale Linki | https://link.springer.com/article/10.10072Fs11010-018-3329-5 | ||
| UAK Araştırma Alanları |
Veteriner Gıda Hijyeni ve Teknolojisi
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| Özet |
| Carvacrol is a natural phenolic compound found in essential oils of Lamiaceae species. In the present study, an attempt has been made to elucidate the mechanism behind the anti-cancer potential of carvacrol on human gastric adenocarcinomas (AGS) by comparing its effects on cancer cells AGS to those on normal human fibroblast (WS-1) cells, in vitro. Cytotoxicity, reactive oxygen species (ROS) generation, glutathione (GSH) levels, genotoxicity, and apoptotic effects of carvacrol (0–600 µM) were studied in both cell lines. Additionally, the effect of high dose carvacrol (100 mg/kg BW) on the oxidative status was investigated in vivo. For this purpose, carvacrol was administered orally to male Wistar rats over a period of 60 days. Rats were weighed regularly. At the end of the experiment, rats were euthanized. Blood and stomach tissues were collected for biochemical and pathological examinations. The in vitro … |
| Anahtar Kelimeler |
| Apoptosis | Carvacrol | Human fibroblast cells | Human gastric adenocarcinoma cells | Oxidative stress status | Pro-oxidant activity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 42 |
| Scopus | 52 |
| Google Scholar | 58 |