Anti-Inflammatory and Antioxidant Effects of Carvacrol on N-Methyl-N-Nitro-N-Nitrosoguanidine (MNNG) Induced Gastric Carcinogenesis in Wistar Rats
Yazarlar (6)
Doç. Dr. Ayşe GÜNEŞ BAYIR Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Eray Metin Güler University Of Health Sciences, Türkiye
Mehmet Gültekin Bilgin
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Dr. Öğr. Üyesi İlyas Samet Ergün Bezmiâlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Abdürrahim Koçyiğit Bezmiâlem Vakıf Üniversitesi, Türkiye
Agnes Dadak
Veterinarmedizinische Universitat Wien, Avusturya
Veterinarmedizinische Universitat Wien, Avusturya
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Nutrients (Q1) | ||
| Dergi ISSN | 2072-6643 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2022 |
| Cilt / Sayı / Sayfa | 14 / 14 / 1–17 | DOI | 10.3390/nu14142848 |
| Makale Linki | https://www.mdpi.com/2072-6643/14/14/2848 | ||
| UAK Araştırma Alanları |
Veteriner Gıda Hijyeni ve Teknolojisi
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| Özet |
| Carvacrol is a dietary polyphenol from Lamiaceae plants that has been shown to possess a wide range of biological activities including antioxidant and antitumor effects. This study aimed to investigate its anti-inflammatory and antioxidant effects on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis in Wistar rats. Forty-nine rats were randomly assigned to four treatment and three control groups. Over 60 days, MNNG (200 mg/kg BW) was orally applied to animals of groups 1–5 while the rats in groups 2–5 also received different doses of carvacrol (10, 25, 50, and 100 mg/kg BW, respectively) until the end of the experiment. Group 6 rats were treated with 100 mg/kg BW carvacrol and no MNNG whereas group 7 was the control group without any treatment. After the euthanasia of all rats, the inflammatory cytokines and oxidative stress parameters were assessed in the blood and tissues. The expression of caspase 9, Bax, and Bcl-2 proteins in the stomach tissues were investigated through histopathological examinations. Statistically significant differences were observed in the body weight, oxidative stress, and inflammation parameters of groups 1 to 6 compared to group 7 (p ≤ 0.001). Animals in MNNG groups 2 and 3 treated with the low dose carvacrol (10 and 25 mg/kg BW) showed significantly reduced oxidative stress, inflammation, and apoptotic effect compared to animals of the MNNG groups receiving increased doses of carvacrol (50 and 100 mg/kg BW) or no carvacrol. Rats exposed to MNNG exhibited gastric cancer cells in several areas. In the MNNG group receiving 100 mg/kg BW carvacrol, the inflammatory … |
| Anahtar Kelimeler |
| anti-inflammatory | antioxidant | carvacrol | gastric cancer | MNNG | Wistar rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 54 |
| Scopus | 61 |
| Google Scholar | 69 |