Medical ozone and radiotherapy in a peritoneal, Erlich-ascites, tumor-cell model
Yazarlar (9)
Hüriye Şenay Kızıltan
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Ayşe GÜNEŞ BAYIR Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Gül Yucesan
Ali Hikmet Eriş
Doç. Dr. Kadir İdin İstanbul Medipol Üniversitesi, Türkiye
Prof. Dr. Cumali Karatoprak Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Teoman Aydın Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Adem Akçakaya Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Alpaslan Mayadağlı Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE (Q4) | ||
| Dergi ISSN | 1078-6791 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2015 |
| Cilt / Sayı / Sayfa | 21 / 2 / 24–29 | DOI | – |
| Makale Linki | https://www.ncbi.nlm.nih.gov/pubmed/25830277 | ||
| UAK Araştırma Alanları |
Anesteziyoloji ve Reanimasyon
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| Özet |
ContextMedical ozone therapy is used for treatment of inflammation in alternative and complementary medicine. It has been reported that the beneficial effects of radiotherapy increased with the addition of medical ozone therapy.ObjectivesThis study intended to investigate the antitumor and antiedema effects of ozone therapy when applied in different concentrations in mice with peritoneal carcinomatosis (PC) and to evaluate the contribution of medical ozone therapy to the outcomes for radiotherapy in vivo.DesignEhrlich ascites carcinoma (EAC) cells were inoculated intraperitoneally (IP) to develop peritoneal carcinomatosis in 60 adult male Swiss albino mice. The animals were divided into 5 groups. Groups 1 and 2 were treated IP for a period of 10 d with daily medical ozone therapy. Group 3 received radiotherapy into the abdomen for 5 d. Groups 4 and 5 were treated with medical ozone therapy for 10 d and radiotherapy for 5 d. Groups 1 and 4 received a 20 mg/L concentration of ozone and groups 2 and 5 received a 40 mg/L concentration. A sixth group acted as controls, and serum physiologic was given to them IP.Outcome measuresChanges in body weight and abdominal circumference were measured daily for each mouse. Survival rates of the groups of mice were also determined. The results were compared between groups and were statistically analyzed.ResultsChanges in body weights and abdominal circumferences in the different groups were statistically different. The longest survival rates were found for groups 3 and 5, and survival rates for the 5 experimental groups were significantly higher than for the control group.ConclusionsMedical ozone therapy or radiotherapy was found to be effective when administered alone or concurrently to mice with PC, suggesting that medical ozone therapy might serve as a method of obtaining antiedema and antitumor effects, providing a longer survival time. |
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