| Yazarlar (9) |
Hüriye Şenay Kızıltan
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
Doç. Dr. Ayşe GÜNEŞ BAYIR
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Gül Yucesan
|
|
Ali Hikmet Eriş
|
|
Kadir İdin
İstanbul Medipol Üniversitesi, Türkiye |
|
Cumali Karatoprak
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Teoman Aydın
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Adem Akçakaya
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Alpaslan Mayadağlı
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
| Özet |
| Medical ozone therapy is used for treatment of inflammation in alternative and complementary medicine. It has been reported that the beneficial effects of radiotherapy increased with the addition of medical ozone therapy. This study intended to investigate the antitumor and antiedema effects of ozone therapy when applied in different concentrations in mice with peritoneal carcinomatosis (PC) and to evaluate the contribution of medical ozone therapy to the outcomes for radiotherapy in vivo. Ehrlich ascites carcinoma (EAC) cells were inoculated intraperitoneally (IP) to develop peritoneal carcinomatosis in 60 adult male Swiss albino mice. The animals were divided into 5 groups. Groups 1 and 2 were treated IP for a period of 10 d with daily medical ozone therapy. Group 3 received radiotherapy into the abdomen for 5 d. Groups 4 and 5 were treated with medical ozone therapy for 10 d and radiotherapy for 5 d. Groups 1 and 4 received a 20 mg/L concentration of ozone and groups 2 and 5 received a 40 mg/L concentration. A sixth group acted as controls, and serum physiologic was given to them IP. Changes in body weight and abdominal circumference were measured daily for each mouse. Survival rates of the groups of mice were also determined. The results were compared between groups and were statistically analyzed. Changes in body weights and abdominal circumferences in the different groups were statistically different. The longest survival rates were found for groups 3 and 5, and survival rates for the 5 experimental groups were significantly higher than for the control group. Medical ozone therapy or radiotherapy was found to be effective when administered alone or concurrently to mice with PC, suggesting that medical ozone therapy might serve as a method of obtaining antiedema and antitumor effects, providing a longer survival time. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE |
| Dergi ISSN | 1078-6791 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2015 |
| Cilt No | 21 |
| Sayı | 2 |
| Sayfalar | 24 / 29 |
| Makale Linki | https://www.ncbi.nlm.nih.gov/pubmed/25830277 |
