| Yazarlar (7) |
Hüriye Şenay Kızıltan
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
Doç. Dr. Ayşe GÜNEŞ BAYIR
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Didem Taştekin
|
|
Ganime Çoban
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Ali Hikmet Eriş
|
|
Teoman Aydın
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
|
Alpaslan Mayadağlı
Bezm-İ Âlem Vakıf Üniversitesi, Türkiye |
| Özet |
| Lung cancer is the most common cancer in males worldwide. The principal mode of treatment in the early stage of non-small cell lung cancer (NSCLC) is surgery. However, five-year survival is only about 15% for all stages. The aim is to investigate the effect of daily low dose cisplatin concurrently with radiation therapy in advanced NSCLC patients with poor performance status. Ten patients diagnosed as inoperable Stage IIIB NSCLC with comorbid disease were assessed retrospectively in Bezmialem Vakif University, Faculty of Medicine, Department of Radiation Oncology, between 2011 to 2013. ECOG performance status was between 3 and 4. Cisplatin was administered at 6 mg/m2 daily, for 5 days a week concurrently with radiotherapy using 160-200 cGy daily fractions, 54 Gy being the lowest and 63 Gy being the highest dose. Complete response at the primary tumour site was obtained in 20% patients. Grade I esophagitis was seen 70 percent of patients, and the grade II haematological toxicity rate was 20%. Median survival time was 7 months. Median survival time was reasonable, despite the patients ECOG performance status of 3-4, which is similar to groups even without comorbid disorders in comparison to other published papers in the literature. Acceptable toxicity, high response rates and quality of life of patients are the other favourable features. |
| Anahtar Kelimeler |
| Daily cisplatin | comorbid disease | thoracic radiochemotherapy | ECOG performance status | NSCLC |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ASIAN PASIFIC JOURNAL OF CANCER PREVENTION |
| Dergi ISSN | 1513-7368 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2014 |
| Cilt No | 15 |
| Sayı | 20 |
| Sayfalar | 8591 / 8594 |
| Doi Numarası | 10.7314/APJCP.2014.15.20.8591 |
| Makale Linki | http://journal.waocp.org/?sid=Entrez:PubMedid=pmid:25374173key=2014.15.20.8591 |
| Atıf Sayıları | |
| WoS | 3 |
| Google Scholar | 5 |
