In vitro effects of two major phenolic compounds from the family Lamiaceae plants on the human gastric AGS cells
 
Yazarlar (3)
Doç. Dr. Ayşe GÜNEŞ BAYIR Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Prof. Dr. Abdürrahim Koçyiğit Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Doç. Dr. Eray Metin Güler Bezm-İ Âlem Vakıf Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Toxicology and Industrial Health (Q3)
Dergi ISSN 0748-2337 Dergi Bilgileri (2018)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 08-2018
Kabul Tarihi – Yayınlanma Tarihi 30-05-2018
Cilt / Sayı / Sayfa 34 / 8 / 525–539 DOI 10.1177/0748233718761698
Makale Linki https://journals.sagepub.com/doi/10.1177/0748233718761698
UAK Araştırma Alanları
Veteriner Gıda Hijyeni ve Teknolojisi
Özet
Phenolic compounds of essential oils from the family Lamiaceae are commonly used substances in the food industry because of their flavouring, antimicrobial and antioxidant properties. In this context, it has become important to have healthy and safe products for consumers who are exposed to these phenolic compounds. The present study was aimed to investigate the toxic effects of carvacrol, thymol and their mixture on human gastric carcinoma (AGS) cells. Cells were analyzed after 24 h of exposure to different concentrations of carvacrol, thymol and their mixture by the ATP cell viability, 2′,7′ dichlorodihydrofluorescein diacetate (H2DCF-DA), reducte glutatione/oxide glutathione ((GSH)/GSSG-Glo) and comet assays. Apoptosis induction was studied by acridine orange/ethidium bromide staining and western blotting. Carvacrol, thymol and their mixture induced cytotoxicity, genotoxicity, apoptosis, increased reactive oxygen species (ROS) and decreased GSH levels after 24 h of their exposure in a dose-dependent manner. A close negative relationship was found between cell viability and ROS generation. We examined dose-dependent cytotoxic effects of carvacrol, thymol and their mixture in human AGS cells. Increased intracellular ROS causes oxidative stress in cells. The results indicated that these compounds should be used carefully in the food industry.
Anahtar Kelimeler
Carvacrol | gastric cells | genotoxicity | pro-oxidant activity | thymol
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Atıf Sayıları
Web of Science 15
Scopus 17
Google Scholar 20
In vitro effects of two major phenolic compounds from the family Lamiaceae plants on the human gastric AGS cells

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İletişim
  • Kastamonu Üniversitesi Rektörlüğü, Kuzeykent Kampüsü, Merkez/Kastamonu
  • unis@kastamonu.edu.tr 03662801000
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