Anticancer, antimicrobial, and DNA protection analysis of novel 2,4-dihydroxyquinoline dyes
Yazarlar (7)
Prof. Dr. Nesrin ŞENER Kastamonu Üniversitesi, Türkiye
Hassan Jaballah Abdullah Mohammed
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Serife Yerlikaya Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mahmut GÜR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. İzzet ŞENER Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Dyes and Pigments (Q1) | ||
| Dergi ISSN | 0143-7208 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2018 |
| Cilt / Sayı / Sayfa | 157 / 1 / 11–19 | DOI | 10.1016/j.dyepig.2018.04.040 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0143720818308726 | ||
| Özet |
| A new series of 2,4-dihydroxyquinoline derived disazo dyes has been synthesized by the reaction of 5-amino-4-phenylazo-3-methyl-1H-pyrazole derivatives with 2,4-dihydroxyquinoline. The structures of the obtained dyes were identified by various spectrophotometric methods such as FT-IR, 1H-NMR, and elemental analysis. The synthesized compounds were also examined for different biological activities, including DNA protection, antimicrobial, and anticancer activities. Compound 3b was found most effective on Gram-positive bacteria. A DNA protection assay was applied to all compounds, and it was found that compounds 3h and 3j had a high capacity for binding to DNA. Besides, compounds 3h and 3j showed cytotoxicity against HeLa and PC3 cancer cell lines. These compounds could potentially be used as drugs or drug additives based on their effects on bacterial and cancer cell lines. |
| Anahtar Kelimeler |
| 2,4-dihydroxyquinoline | Anti-cancer | Antimicrobial activity | Diazotization | Disazo dyes | DNA protection |
Science Direct
Anticancer, antimicrobial, and DNA protection analysis of novel 2,4-dihydroxyquinoline dyes
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 14 |
| Google Scholar | 21 |