Comparative Content, Biological and Anticancer Activities of Heracleum humile Extracts Obtained by Ultrasound-Assisted Extraction Method
Yazarlar (8)
Arş. Gör. Mustafa ÖÇAL Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Simone Angeloni Università Degli Studi Di Camerino, İtalya
Ahmed M. Mustafa Università Degli Studi Di Camerino, İtalya
Giovanni Caprioli Università Degli Studi Di Camerino, İtalya
Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye
Mehmet Yavuz Paksoy Munzur University, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2022 |
| Kabul Tarihi | 27-05-2022 | Yayınlanma Tarihi | 15-06-2022 |
| Cilt / Sayı / Sayfa | 19 / 7 / 1–15 | DOI | 10.1002/cbdv.202101040 |
| Makale Linki | http://dx.doi.org/10.1002/cbdv.202101040 | ||
| Özet |
| As the safety and effectiveness of synthetic drugs remain in doubt, researchers are trying to develop natural medicines from medicinal plants. Herein, ethyl acetate, methanol and water extracts from the Heracleum humile plant were obtained by an ultrasonic‐assisted extraction process and the aim was to evaluate some biological effects of the extracts due to the limited data on the pharmacological properties of Heracleum humile in the literature. Weak antibacterial activity was observed on tested bacterial species. The minimum inhibitory concentration and the minimum bactericidal concentration values ranged from 250 to 500 μg/mL. In addition, cytotoxic activity was determined using the MTT test. The strongest findings were determined for ethyl acetate extract on the MDA‐MB‐231 cell lines at the 48th hour (IC50:97.94 μg/mL), followed by the MCF‐7 cell lines at the 24th hour (IC50:103.9 μg/mL). All extracts … |
| Anahtar Kelimeler |
| anticancer | different extracts | enzyme inhibitor | Heracleum humile | ultrasound-assisted extraction |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 5 |
| Google Scholar | 10 |