Evaluation of changes in myelination in the brain during infancy and childhood using ADC maps
Yazarlar (3)
Prof. Dr. Mustafa Özkan Türkiye
Doç. Dr. İsmail TAŞKENT Kastamonu Üniversitesi, Türkiye
Memik Teke
Türkiye
Türkiye
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Surgery and Medicine | ||
| Dergi ISSN | 2602-2079 | ||
| Dergi Tarandığı Indeksler | Directory of Research Journals Indexing (DRJI) | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2019 |
| Cilt / Sayı / Sayfa | 3 / 11 / 785–789 | DOI | 10.28982/josam.633584 |
| Makale Linki | https://doi.org/10.28982/josam.633584 | ||
| UAK Araştırma Alanları |
Radyoloji
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| Özet |
| Aim Myelinization has a critical role in achieving rapid synchronization between the neural system and high-grade cognitive functions. Because of this critical role, it is important to quantitatively determine the degree of myelination. Today, structural changes due to myelination can be evaluated quantitatively by diffusion magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) measurements. The aim of this study was to evaluate myelination-related changes in different regions of the brain during infancy and childhood in the normal population by measuring ADC values in routine MRI examinations. Methods In this cross-sectional study, 109 patients aged 0-17 years who underwent brain MRI examination with 3.0T device and whose myelination and maturation were interpreted as normal in conventional sequences were evaluated. In all examinations, ADC maps from 30 different locations were evaluated and measured in the workstation based on T2-weighted images. Results There is a functional relationship between ADC values and the myelination process during infancy and childhood in the normal population. ADC values decrease in all localizations with increasing age, especially during the first 2 years. During the postnatal period, ADC values, which are higher in the white matter, decrease as maturation of white matter is completed and increase in the cortical gray matter. No significant difference was found between bilateral structures except the thalamus, caudate nucleus or centrum semiovale regions. There was no gender-dependent significant difference in the patients aged between zero and 2 years. Conclusion … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |