| Yazarlar |
Aysenur Aygun
|
|
Fulya Gülbagca
|
|
Lutfiye Yildiz Ozer
|
|
Buket Ustaoğlu
|
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Mehmet Nuri Atalar
Iğdır Üniversitesi, Türkiye |
|
Mehmet Hakkı Alma
|
|
Fatih Şen
Kütahya Dumlupınar Üniversitesi, Türkiye |
| Özet |
| Herein, the biogenic platinum nanoparticles (Pt NPs) were synthesized by using black cumin seed (Nigella sativa L.) extract as a reducing agent. The biogenic platinum nanoparticles synthesized by black cumin seed extract was characterized in detail by Transmission Electron Microscopy (TEM), UV–vis spectrophotometer, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS). According to TEM analysis, Pt nanoparticles have spherical shapes and sizes between 1–6 nm. Moreover, the biogenic Pt NPs was assessed for its cytotoxicity effect on MDA-MB-231 breast and HeLa cervical cancer lines and their antibacterial effect against selected strains of gram-positive and negative bacteria. The cytotoxicity and bacterial tests showed the effectiveness of biogenic Pt nanoparticles. Dose-dependent toxicity effects were shown in the MDA-MB-231 breast and HeLa cervical cancer lines (IC50: 36.86 μg/mL and 19.83 μg/mL, respectively). In addition, Pt NPs showed high zone diameters against gram-positive and gram-negative bacteria at concentrations of 100 and 500 μg/ml. These results contribute to the development of the pharmaceutical industry as a potential antibacterial and anticancer agent. |
| Anahtar Kelimeler |
| Biogenic platinum nanoparticles,Nigella sativa L.,Antibacterial,Anticancer,MDA-MB-231,HeLa cervical cancer lines |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Pharmaceutical and Biomedical Analysis |
| Dergi ISSN | 0731-7085 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2019 |
| Cilt No | 179 |
| Sayfalar | 112961 / |
| Doi Numarası | 10.1016/j.jpba.2019.112961 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0731708519321375 |
| Atıf Sayıları | |
| WoS | 82 |
| SCOPUS | 106 |
