| Yazarlar |
Şengül Uysal
Erciyes Üniversitesi, Türkiye |
|
Reneta Gevrenova
|
|
Kouadio Ibrahime Sinan
|
Dr. Öğr. Üyesi Aslı UĞURLU BAYARSLAN
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Dimitrina Zheleva-Dimitrova
|
|
Güneş Ak
|
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Ouattara Katinan Etienne
|
|
Devina Lobine
|
|
M. Fawzi Mahomoodally
|
|
Gökhan Zengin
Selçuk Üniversitesi, Türkiye |
| Özet |
| The chemical components, in vitro antioxidant capacities and enzyme inhibitory effects of dichloromethane (DCM), ethyl acetate (EA), methanol (MeOH) and water extracts of the medicinal plant, Sida acuta Burm. f. were evaluated. The individual phenolic components were assessed via ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS). In terms of chemical composition, phenolics (hydroxybenzoic and hydroxycinnamic acids) and flavonoids were identified as main groups. The antioxidant capacities were evaluated using a panoply of cell-free bioassays and the enzymatic inhibitory potentials against key enzymes involved in human diseases were also determined. The water extract exhibited the strongest scavenging abilities on DPPH (IC50: 1.05 mg/mL) and ABTS (IC50: 1.02 mg /mL). The best cholinesterase inhibitory abilities were observed with the methanol extract (IC50: 0.51 and 0.52 mg/mL for AChE and BChE, respectively), while DCM exhibited the strongest α-amylase (IC50: 1.21 mg/mL) and α-glucosidase (IC50: 0.62 mg/mL) inhibitory effects. The anti-cancer effects of methanol and water extracts were tested on human breast cancer cells, MDA-MB-231, and the methanol extract showed the best anti-cancer effect with an IC50 value of 102.4 μg/mL. In conclusion, the experimental data have demonstrated promising pharmacological activities of S. acuta extracts obtained using different solvents, thereby providing a scientific basis for the validation of the traditional medicinal uses of this plant. |
| Anahtar Kelimeler |
| Anti-cancer,Bioactive compounds,Cholinesterase,Radical scavenging,Sida acuta,Solvents |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Process Biochemistry |
| Dergi ISSN | 1359-5113 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2021 |
| Cilt No | 105 |
| Sayı | 1 |
| Sayfalar | 91 / 101 |
| Doi Numarası | 10.1016/j.procbio.2021.03.028 |
| Makale Linki | http://dx.doi.org/10.1016/j.procbio.2021.03.028 |
| Atıf Sayıları | |
| SCOPUS | 12 |
| Google Scholar | 18 |
