Exploring of Coronilla varia L. extracts as a source of high-value natural agents: Chemical profiles and biological connections
Yazarlar (7)
Dr. Öğr. Üyesi Şerife Yerlikaya Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Alina Diuzheva Czech University Of Life Sciences Prague, Çek Cumhuriyeti
József Jekő University Of Nyíregyháza, Macaristan
Zoltán Cziáky University Of Nyíregyháza, Macaristan
Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | South African Journal of Botany (Q2) | ||
| Dergi ISSN | 0254-6299 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-12-2021 |
| Cilt / Sayı / Sayfa | 143 / 1 / 382–392 | DOI | 10.1016/j.sajb.2021.02.025 |
| Makale Linki | http://dx.doi.org/10.1016/j.sajb.2021.02.025 | ||
| Özet |
| Pharmacological studies have indicated that flavonoids are crucial compounds to eliminate drug resistance. In this report, the activity of ethyl acetate (EAE), methanol (ME) and water (WE) extracts of Coronilla varia L. on antioxidant and enzyme inhibitory activities, DNA protective effects, antiproliferative activities, apoptotic; autophagic and telomerase gene activity analysis in breast cancer cells and inhibitory effects on cell migration ability of malignant breast cancer cells were examined. In addition, HPLC-MS-MS was used for detection of chemical profiles of all extracts. Results showed that the highest concentration of the bioactive components was detected in EAE (50.86 mg GAE/g for phenolics and 25.66 mg RE/g for flavonoid). Also, EAE displayed significant antioxidant properties in radical scavenging and reducing power assays. Regarding enzyme inhibitory effects, EAE and ME were more active than WE … |
| Anahtar Kelimeler |
| Antioxidant | Apoptosis | Cell migration | Crown vetch | DNA protection |
Science Direct
Exploring of Coronilla varia L. extracts as a source of high-value natural agents: Chemical profiles and biological connections
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |
| Scopus | 9 |
| Google Scholar | 9 |