Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents
Yazarlar (10)
Mohamad Fawzi Mahomoodally University Of Mauritius, Mauritius
Elwira Sieniawska Medical University Of Lublin, Polonya
Kouadio Ibrahime Sinan Selçuk Üniversitesi, Türkiye
Marie Carene Nancy Picot-Allain University Of Mauritius, Mauritius
Dr. Öğr. Üyesi Serife Yerlikaya Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ismail Senkardes Marmara Üniversitesi, Türkiye
Kannan Rr Rengasamy Konkuk University, Güney Kore
Gokhan Zengin Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food and Chemical Toxicology | ||
| Dergi ISSN | 0278-6915 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2020 |
| Cilt / Sayı / Sayfa | 135 / 1 / 111052–0 | DOI | 10.1016/j.fct.2019.111052 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0278691519308427 | ||
| Özet |
| Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of ‘mad honey’ poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum … |
| Anahtar Kelimeler |
| Anticancer | Enzyme inhibitory | Honeysuckle azalea | PCA analysis | Yellow azalea |
Science Direct
Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 21 |
| Google Scholar | 31 |