| Yazarlar |
Ayşenur Aygün
|
|
Fulya Gülbağça
|
|
Mehmet Salih Nas
Iğdır Üniversitesi, Türkiye |
|
Mehmet Hakkı Alma
|
|
Mehmet Harbi Çalımlı
Iğdır Üniversitesi, Türkiye |
|
Buket Ustaoğlu
|
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Kemal Cellat
|
|
Fatih Şen
Kütahya Dumlupınar Üniversitesi, Türkiye |
| Özet |
| This paper reports the anticarcinogenic and antimicrobial properties of silver nanoparticles (Ag NPs) obtained by green synthesis using the extract of Rheum ribes (R. ribes), a medicinal plant. For the synthesis of Ag NPs, the ethanolic extracts of R. ribes were used as a reducing as well as the stabilizing agent. For the characterization of Ag NPs, advanced analytical methods such as transmission electron microscopy (TEM), X-Ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and UV–vis spectrophotometry were performed. The synthesized Ag NPs obtained from R. ribes were evaluated as a cytotoxic agent against MDA-MB-231 breast carcinoma cell line. The IC50 values of the nanoparticles were ranged from 165 to 99 μg/mL against MDA-MB 231 cell line for 24 h and 48 h, respectively. The results show that the use of Ag NPs at low concentrations show the toxic effect in the cancer cells. In addition, the results of experiments on gram-positive (Staphylococcus aureus (S. aureus), Methicillin-resistant Staphylococcus aureus (MRSA) and Bacillus subtilis (B. subtilis)) and gram-negative (Escherichia coli (E. coli)) bacteria showed that the Ag NPs had high antimicrobial activity. The results suggest that Ag NPs can be developed as potential anticancer and antibacterial agents. |
| Anahtar Kelimeler |
| Ag nanoparticle,Anticancer,Antimicrobial,Characterization,Green synthesis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Pharmaceutical and Biomedical Analysis |
| Dergi ISSN | 0731-7085 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2020 |
| Cilt No | 179 |
| Sayfalar | 113012 / |
| Doi Numarası | 10.1016/j.jpba.2019.113012 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0731708519322629 |
