Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
Yazarlar (9)
Öğr. Gör. Tevfik Hasan Can Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Enis Fuat TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Eulogio J Llorent-Martínez Universidad De Jaén, İspanya
Azzurra Stefanucci University Of G. D'annunzio Chieti And Pescara, İtalya
Adriano Mollica University Of G. D'annunzio Chieti And Pescara, İtalya
Angelo Cichelli University Of G. D'annunzio Chieti And Pescara, İtalya
Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Computational Biology and Chemistry | ||
| Dergi ISSN | 1476-9271 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-08-2020 |
| Cilt / Sayı / Sayfa | 87 / 1 / 107273–0 | DOI | 10.1016/j.compbiolchem.2020.107273 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S1476927120301481 | ||
| Özet |
| The scientific world tends to turn to natural products such as medicinal and aromatic plants because of the inadequacy of commercially available synthetic drugs as antibiotics or anticancer, and their adverse effects on healthy tissues. One of these plants is Daphne gnidioides Jaub. & Spach, which belongs to the Thymelaeaceae family, and there is no data in the literature on its biological activity. This study is aimed to elucidate the chemical profiles and in vitro anticancer, antibacterial and DNA protection and enzyme inhibitory properties of methanol extracts of root, stem, and leaf of D. gnidioides Jaub. & Spach. Polyphenolic components of the extracts were characterized by HPLC-MS/MS. The highest phenolic content was detected in the leaf extract (TIPC = 43.5 ± 0.5 mg/g DE), followed by stem (TIPC = 27.3 ± 0.7 mg/g DE) and root (TIPC = 18.3 ± 0.2 mg/g DE) extracts. Vicenin-2 and 3-O-p-coumaroyl-5-O … |
| Anahtar Kelimeler |
| Antibacterial | anticancer | coumaroly-CQA | Daphne gnidioides Jaub. & Spach | HeLa cells | vicenin-2 |
Science Direct
Chemical characterization, computational analysis and biological views on Daphne gnidioides Jaub. Spach extracts: Can a new raw material be provided for biopharmaceutical applications?
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 13 |
| Scopus | 14 |
| Google Scholar | 22 |