Analysis of DNA protection, interaction and antimicrobial activity of isatin derivatives
Yazarlar (7)
Mohamed Abdulhamıd Ganım
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Aysenur Aygun Dumlupinar Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Hakan Sezgin Sayiner Adıyaman Üniversitesi, Türkiye
Prof. Dr. Fatma Kandemirli Kastamonu Üniversitesi, Türkiye
Prof. Dr. Fatih Şen Kütahya Dumlupınar Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Biological Macromolecules (Q1) | ||
| Dergi ISSN | 0141-8130 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-02-2019 |
| Cilt / Sayı / Sayfa | 122 / 1 / 1271–1278 | DOI | 10.1016/j.ijbiomac.2018.09.084 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0141813018325686 | ||
| Özet |
| Isatin, thiosemicarbazone and their derivatives have been widely used in biological applications such as antimicrobial, antiviral and anticancer therapies. Herein, eight isatin and thiosemicarbazone derivative compounds were re-synthesized and evaluated for DNA binding analysis including DNA protection studies using plasmid DNA (pUC19) and DNA interaction experiments using calf thymus DNA (CT-DNA). All compounds were also utilized in vitro assay to assess the antimicrobial activity of compounds against different pathogenic bacterial strains. All isatin and thiosemicarbazone derivative compounds exhibited DNA protection activity which ranged from 23.5 to 59.5%. Among them, I3-(N-2-MP)-TSC had the greatest DNA protective activity. For DNA binding analysis, all compounds had the same constant concentration (40 μM), which interacts with CT-DNA. It was also observed that DNA interactions gave a … |
| Anahtar Kelimeler |
| Antimicrobial activity | DNA binding analysis | Isatin thiosemicarbazone derivatives |
Science Direct
Analysis of DNA protection, interaction and antimicrobial activity of isatin derivatives
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 25 |
| Scopus | 27 |
| Google Scholar | 36 |