Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
Yazarlar (9)
Marcello Locatelli University Of G. D'annunzio Chieti And Pescara, İtalya
Dr. Öğr. Üyesi Serife Yerlikaya Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Francesco Cacciagrano University Of G. D'annunzio Chieti And Pescara, İtalya
Cristina Campestre University Of G. D'annunzio Chieti And Pescara, İtalya
Mohamad Fawzi Mahomoodally University Of Mauritius, Mauritius
Adriano Mollica University Of G. D'annunzio Chieti And Pescara, İtalya
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food and Chemical Toxicology | ||
| Dergi ISSN | 0278-6915 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2018 |
| Cilt / Sayı / Sayfa | 120 / 1 / 172–182 | DOI | 10.1016/j.fct.2018.07.012 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0278691518304502 | ||
| Özet |
| This study aims to establish the biological and chemical profile of Asphodeline liburnica (Scop.) Rchb. root. The antioxidant, antimicrobial, enzyme inhibitory, DNA protection, apoptotic DNA ladder fragmentation analysis, and anti-proliferative of A. liburnica were established using standard assays. In silico study was also performed to understand interactions between quantified anthraquinones and key enzymes of clinical relevance. Total phenolic and flavonoid contents were found to be 9.67 mgGAE/g and 1.48 mgRE/g extract, respectively. Chrysophanol was detected as a major anthraquinone. The extract exhibited radical scavenging ability against DPPH and ABTS with values of 13.23 and 66.99 mgTE/g extract, respectively. Good inhibitory activity against tyrosinase was recorded. In silico experiments showed that the anthraquinones were able to establish coordinative bonds with the copper atoms present in the … |
| Anahtar Kelimeler |
| Anthraquinones | Asphodeline liburnica | Chrysophanol | Cytotoxicity | DNA protection | HPLC analysis |
Science Direct
Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 13 |
| Google Scholar | 18 |