Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
Yazarlar (10)
Doç. Dr. Şengül Uysal Selçuk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Aslı Uğurlu Bayarslan Kastamonu Üniversitesi, Türkiye
Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Adriano Mollica University Of G. D'annunzio Chieti And Pescara, İtalya
Luisa Custodio
Universidade Do Algarve, Portekiz
Universidade Do Algarve, Portekiz
Nuno R Neng Faculdade De Ciências Da Universidade De Lisboa, Portekiz
José Mf Nogueira Faculdade De Ciências Da Universidade De Lisboa, Portekiz
M Fawzi Mahomoodally University Of Mauritius, Mauritius
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food and Chemical Toxicology | ||
| Dergi ISSN | 0278-6915 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2018 |
| Cilt / Sayı / Sayfa | 111 / 1 / 525–536 | DOI | 10.1016/j.fct.2017.11.058 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S027869151730738X | ||
| Özet |
| Bidens tripartita L. is a traditional phyto-remedy used in several countries, yet there is still a paucity of data on its biological potential. We aimed to provide new insights on the pharmacological potential of extracts prepared from B. tripartita via highlighting its antioxidant, key enzymes inhibitory potency, and DNA protecting effects. Phytochemical profile was established using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) and bioactive compound(s) docked against target enzymes using in silico methods. Cytotoxicity against three cancer cell lines was assessed using the methylthiazolyldiphenyl-tetrazolium bromide (MTT) cell viability test. The main compounds were luteolin-7-glucoside (cynaroside), chlorogenic acid, and epicatechin in the extracts. The methanol extract exhibited the highest radical scavenging activity. Ethyl acetate extract showed strongest α-amylase inhibitory … |
| Anahtar Kelimeler |
| Anti-cancer | Anti-proliferative | Antioxidant | Cholinesterases | DNA protection | α-glucosidase |
Science Direct
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 43 |
| Scopus | 51 |
| Google Scholar | 85 |